Advanced technologies enabled by 3D bioprinting

Efficacy, safety and advanced technologies enabled by 3D bioprinting.

3D bioprinting is an advanced technology that enables the fabrication of living three-dimensional tissues. This technique allows the creation of complex cellular structures without the need for moulds, while maintaining strict control over cell geometry, density and spatial distribution. It represents a transformative tool that brings in vitro models closer to in vivo behaviour. At AINIA, we place this technology at the service of your innovation to help you develop more effective, safer and more sustainable products.

  • Higher predictivity: three-dimensional models more accurately replicate the native cellular microenvironment.
  • Application of the 3Rs principle (reduction, refinement and replacement): contributes to reducing or replacing the use of animals in experimentation.
  • Lower experimental risk: enables decision-making based on functional and biological data, such as cell viability, specific biomarkers and tissue response.
  • Competitiveness and technology transfer: provides robust evidence for claim substantiation and regulatory support, with protocols scalable to pilot or preindustrial level.

3D Bioprinting in Food

Integrated digestive and cellular models to analyse bioaccessibility, bioavailability and the functional effect of ingredients.

At AINIA, we work with advanced technologies to reproduce, under laboratory conditions, processes that occur in the human body. This allows us to study how foods and their ingredients behave before reaching the consumer.
  • On the one hand, we use dynamic digestive models that simulate the different stages of gastrointestinal digestion and colonic fermentation. Thanks to these systems, we can evaluate bioaccessibility (the fraction of a compound released after digestion) and bioavailability (the fraction that can be absorbed by the body) of functional ingredients and innovative foods.
  • On the other hand, we apply 3D bioprinting to create cellular structures that act as scaffolds in the development of cultivated meat, a promising alternative for more sustainable protein production, as well as for the creation of advanced cellular models.
These tools open the door to healthier, safer and more environmentally responsible food systems.
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3D Bioprinting in Dermocosmetics

Safety, hydration, pigmentation and cellular regeneration without animal testing.

At AINIA, we apply 3D bioprinting to generate three-dimensional human skin models that faithfully reproduce skin structure and physiological behaviour, enabling more precise evaluation of the efficacy and safety of cosmetic ingredients and formulations without the need for animal testing.
These models are essential for assessing the efficacy and safety of ingredients, formulations or finished products by measuring performance parameters such as hydration, regeneration, collagen and elastin synthesis, or pigmentation modulation, among others.

In addition, 3D bioprinting provides an ethical and highly precise alternative to animal testing, while also enabling rapid comparative studies to optimise formulations at early stages of development.

3D Bioprinting in the Pharmaceutical Sector

More precise evaluation of mechanisms of action, efficacy and toxicity.

3D bioprinting enables the creation of predictive human tissue models for evaluating mechanisms of action, efficacy and toxicity. By combining 3D bioprinting with advanced cell culture techniques and omics analysis, we deliver reproducible and predictive models that accelerate R&D and provide solid evidence for decision-making at early stages of pharmaceutical development. At AINIA, this technology is applied to drug screening, the development of disease-specific models and the optimisation of pharmaceutical dosage forms through the analysis of penetration, dissolution and bioavailability of active compounds.
digestor dinamico
organ on chip
Bioimpresion

At AINIA, we add value

At AINIA, we enhance 3D bioprinting by integrating it with other advanced technologies to deliver more precise and transferable results.

  • Organ-on-chip
  • Organoids
  • Dynamic colonic fermentation digester
  • Omics technologies.

This integration allows us to recreate the full interaction pathway between compounds and the human body, from digestion and absorption to their biological effect on target tissues, generating functional and molecular data with high predictive value. With more than ten years of experience in biotechnology and advanced analysis, we provide companies with a robust technological environment to:

  • Accelerate innovation by reducing time and costs in preclinical phases.
  • Optimise development decisions based on functional and molecular evidence.
  • Generate reproducible and transferable results scalable to pilot or industrial level.

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Lidia Tomás
Head of Preclinical in vitro Studies