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Neste artigo explicamos tudo sobre o probi\u00f3tico<\/strong> Lactobacillus reuteri<\/strong><\/em>, conhecido pela sua capacidade de modular a microbiota, produzir compostos antimicrobianos e apoiar a barreira intestinal. Tamb\u00e9m iremos rever as propriedades, tipos\/estirpes<\/strong> mais utilizados, os benef\u00edcios<\/strong> e as chaves de conce\u00e7\u00e3o e avalia\u00e7\u00e3o<\/strong> necess\u00e1rias para os transformar em produtos vi\u00e1veis.<\/p>\n<\/nav>\n

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Lactobacillus reuteri<\/em>: propriedades, benef\u00edcios e aplica\u00e7\u00f5es<\/a><\/strong><\/li>\n
Propriedades de Lactobacillus reuteri<\/em><\/a><\/strong><\/li>\n
Benef\u00edcios do probi\u00f3tico Lactobacillus reuteri<\/em><\/a><\/strong><\/li>\n
Aplica\u00e7\u00f5es industriais emergentes<\/a><\/strong><\/li>\n
Probi\u00f3tico Lactobacillus reuteri<\/em>: tipos<\/a><\/strong><\/li>\n
Probi\u00f3tico Lactobacillus reuteri<\/em>: conce\u00e7\u00e3o e avalia\u00e7\u00e3o<\/a><\/strong><\/li>\n<\/ul>\n<\/section>\n\n
Propriedades de Lactobacillus reuteri<\/em>: para que serve?<\/strong><\/h2>\nOs probi\u00f3ticos<\/strong><\/a> s\u00e3o amplamente conhecidos pelos seus benef\u00edcios na sa\u00fade digestiva, imunol\u00f3gica e at\u00e9 oral. O probi\u00f3tico Lactobacillus reuteri<\/em><\/strong> \u00e9 um microrganismo<\/strong> que coloniza naturalmente o trato gastrointestinal de humanos e outros mam\u00edferos. Destaca-se por tr\u00eas propriedades funcionais principais:<\/p>\n
\n
Capacidade de ades\u00e3o e modula\u00e7\u00e3o da microbiota:<\/strong>
\nAdere \u00e0 mucosa intestinal, ajudando a equilibrar a microbiota<\/strong> e a favorecer uma comunidade mais est\u00e1vel.<\/li>\n
Produ\u00e7\u00e3o de compostos bioativos:<\/strong>
\nAlgumas estirpes, capazes de metabolizar glicerol, produzem reuterina<\/strong> e outras subst\u00e2ncias antimicrobianas que inibem<\/strong> pat\u00f3genos<\/strong> (por exemplo, enterobact\u00e9rias ou Candida), contribuindo para a prote\u00e7\u00e3o colonizadora.<\/li>\n
Al\u00e9m disso, a reuterina<\/strong> atua contra microrganismos patog\u00e9nicos como: E. coli, Salmonella, Clostridioides difficile ou Candida albicans. A sua atividade n\u00e3o depende do pH<\/strong> e \u00e9 eficaz em baixas concentra\u00e7\u00f5es. Isto torna-a um diferencial claro face a outros probi\u00f3ticos.<\/li>\n
Efeito imunomodulador:<\/strong> pode modular a resposta inflamat\u00f3ria<\/strong> e apoiar a barreira<\/strong> intestinal<\/strong>, com impacto potencial em desconfortos digestivos funcionais (por exemplo, epis\u00f3dios de dor abdominal, distens\u00e3o ou tr\u00e2nsito alterado).<\/li>\n<\/ul>\n<\/section>\n
$\"Digestive$ \n
Benef\u00edcios do probi\u00f3tico Lactobacillus reuteri<\/em><\/strong><\/h3>\n
Os benef\u00edcios potenciais dependem da estirpe<\/strong>, da dose eficaz<\/strong>, da qualidade da formula\u00e7\u00e3o<\/strong> e da popula\u00e7\u00e3o-alvo<\/strong>.<\/p>\n
Os benef\u00edcios mais relevantes do probi\u00f3tico Lactobacillus reuteri<\/em> s\u00e3o:<\/p>\n
\n
Sa\u00fade digestiva:<\/strong> apoio em diarreias agudas, preven\u00e7\u00e3o da diarreia associada a antibi\u00f3ticos, desconfortos gastrointestinais funcionais e regula\u00e7\u00e3o do tr\u00e2nsito intestinal.<\/li>\n
Sa\u00fade oral:<\/strong> redu\u00e7\u00e3o da placa e da halitose, e apoio \u00e0s gengivas.<\/li>\n
Sa\u00fade infantil:<\/strong> apoio digestivo em lactentes.<\/li>\n
Sa\u00fade metab\u00f3lica\/inflamat\u00f3ria:<\/strong> sinais de modula\u00e7\u00e3o de citocinas e do eixo intestino-sistema imunit\u00e1rio.<\/li>\n<\/ul>\n<\/section>\n
\n
Aplica\u00e7\u00f5es industriais emergentes<\/strong><\/h3>\n
\n
Biofilmes ben\u00e9ficos na aquicultura:<\/strong> algumas estirpes s\u00e3o utilizadas para competir com Vibrio.<\/li>\n
Utiliza\u00e7\u00e3o na alimenta\u00e7\u00e3o animal:<\/strong> melhoria da sa\u00fade intestinal em leit\u00f5es e aves.<\/li>\n
Aplica\u00e7\u00f5es em sa\u00fade oral (PTA 5289):<\/strong><\/li>\n<\/ul>\n
\n
redu\u00e7\u00e3o de Streptococcus mutans<\/em><\/li>\n
modula\u00e7\u00e3o do biofilme oral<\/li>\n
utiliza\u00e7\u00e3o em pr\u00f3teses dent\u00e1rias<\/li>\n<\/ol>\n<\/section>\n
\n
Probi\u00f3tico Lactobacillus reuteri<\/em>: tipos<\/h2>\n
Nos probi\u00f3ticos, o tipo de estirpe define a utiliza\u00e7\u00e3o, a evid\u00eancia cient\u00edfica e a forma ideal de formula\u00e7\u00e3o.<\/p>\n
Estes s\u00e3o os crit\u00e9rios que deve considerar ao selecionar uma estirpe:<\/strong><\/p>\n
\n
Indica\u00e7\u00e3o e popula\u00e7\u00e3o-alvo claramente definidas<\/li>\n
Estirpe com dossi\u00ea cient\u00edfico rastre\u00e1vel e dep\u00f3sito em cole\u00e7\u00e3o reconhecida<\/li>\n
Dose eficaz expressa em UFC por dia e forma de administra\u00e7\u00e3o adequada<\/li>\n
Estabilidade real ao longo da vida \u00fatil e compatibilidade com os restantes ingredientes<\/li>\n
Conformidade regulamentar e estrat\u00e9gia de rotulagem clara<\/li>\n<\/ul>\n
Estirpe DSM 17938<\/strong><\/h3>\n
\u00c9 a refer\u00eancia mais utilizada na sa\u00fade digestiva, com especial foco na popula\u00e7\u00e3o infantil. A evid\u00eancia cient\u00edfica apoia os seus benef\u00edcios gastrointestinais, a redu\u00e7\u00e3o de epis\u00f3dios de diarreia e o equil\u00edbrio do tr\u00e2nsito intestinal.<\/p>\n
\u00c9 frequentemente utilizada em formula\u00e7\u00f5es l\u00edquidas e em p\u00f3, com matrizes concebidas para proteger a viabilidade<\/a> <\/strong>durante o armazenamento e a utiliza\u00e7\u00e3o.<\/p>\n
Estirpe ATCC PTA 6475<\/strong><\/h3>\n
Selecionada pelo seu perfil imunomodulador e pelo apoio \u00e0 integridade da barreira intestinal. Destina-se a adultos e a desenvolvimentos que procuram modular inflama\u00e7\u00e3o de baixo grau.<\/p>\n
Requer um trabalho cuidadoso de estabilidade e de sele\u00e7\u00e3o de excipientes que preservem a funcionalidade e a contagem vi\u00e1vel.<\/p>\n
Estirpe ATCC PTA 5289<\/strong><\/h3>\n
Habitual em solu\u00e7\u00f5es de sa\u00fade oral. Tem sido utilizada em combina\u00e7\u00f5es focadas na redu\u00e7\u00e3o da placa, controlo do mau h\u00e1lito e cuidado gengival.<\/p>\n
A forma de administra\u00e7\u00e3o pode assumir diferentes formatos:<\/p>\n
\n
Comprimidos bucais<\/li>\n
Gomas<\/li>\n
Formatos de liberta\u00e7\u00e3o local<\/li>\n<\/ul>\n
Estes formatos maximizam o contacto com o biofilme e potenciam o efeito.<\/p>\n
Estirpe ATCC 55730<\/strong><\/h3>\n
Historicamente relevante pela sua utiliza\u00e7\u00e3o cl\u00ednica, embora a sua substitui\u00e7\u00e3o pela DSM 17938 tenha respondido a crit\u00e9rios de seguran\u00e7a relacionados com determina\u00e7\u00f5es de resist\u00eancia a antibi\u00f3ticos.<\/p>\n<\/section>\n
\n
Probi\u00f3tico Lactobacillus reuteri<\/em>: conce\u00e7\u00e3o e avalia\u00e7\u00e3o<\/h2>\n
Para transformar um probi\u00f3tico num produto competitivo, fi\u00e1vel, seguro e eficaz<\/strong>, o desenvolvimento deve integrar a sele\u00e7\u00e3o de estirpes, formula\u00e7\u00e3o, valida\u00e7\u00e3o pr\u00e9-cl\u00ednica e cl\u00ednica, bem como uma estrat\u00e9gia regulamentar e de vida \u00fatil coerente.<\/p>\n
Na AINIA abordamos todo o ciclo com foco no desempenho real do probi\u00f3tico e na sua viabilidade at\u00e9 ao final da vida \u00fatil<\/strong>.<\/p>\n
\n
Defini\u00e7\u00e3o da indica\u00e7\u00e3o e sele\u00e7\u00e3o de estirpes:<\/strong> definimos o objetivo de sa\u00fade e, a partir da\u00ed, estabelecemos o posicionamento: dose, forma de administra\u00e7\u00e3o e futuros endpoints cl\u00ednicos.<\/li>\n
Formula\u00e7\u00e3o e estabilidade:<\/strong> otimizamos a matriz e os excipientes para proteger a viabilidade do microrganismo<\/strong> face ao oxig\u00e9nio, humidade e temperatura. Utilizamos tecnologias de estabiliza\u00e7\u00e3o comprovadas, como liofiliza\u00e7\u00e3o e secagem por atomiza\u00e7\u00e3o, e validamos o seu impacto na contagem vi\u00e1vel e na funcionalidade.<\/li>\n
Valida\u00e7\u00e3o pr\u00e9-cl\u00ednica com modelos avan\u00e7ados:<\/strong> verificamos a sobreviv\u00eancia g\u00e1strica e intestinal e a funcionalidade atrav\u00e9s de um Digestor Din\u00e2mico in vitro, modelos de fermenta\u00e7\u00e3o col\u00f3nica e modelos celulares<\/a> que permitem estudar a resist\u00eancia gastrointestinal, a absor\u00e7\u00e3o e a modula\u00e7\u00e3o da microbiota.<\/li>\n
Transla\u00e7\u00e3o cl\u00ednica e estrat\u00e9gia regulamentar:<\/strong> desenhamos estudos cl\u00ednicos alinhados com a indica\u00e7\u00e3o e a popula\u00e7\u00e3o-alvo, com vari\u00e1veis como dias de diarreia, conforto digestivo ou marcadores de inflama\u00e7\u00e3o, e colaboramos com centros de sa\u00fade para obter evid\u00eancia s\u00f3lida. Em paralelo, definimos o enquadramento regulamentar do produto, a rotulagem e os requisitos de qualidade.<\/li>\n
Escala e controlo da vida \u00fatil:<\/strong> levamos o desenvolvimento \u00e0 escala piloto e industrial, selecionando embalagens barreira e condi\u00e7\u00f5es log\u00edsticas que preservem a viabilidade. Ao longo do processo realizamos estudos de estabilidade acelerada e em condi\u00e7\u00f5es reais, e revalidamos o desempenho na digest\u00e3o in vitro quando existem altera\u00e7\u00f5es significativas de formula\u00e7\u00e3o $\"Genocare\"$ Financiado pelo programa de\u00a0<\/span>apoios<\/span>\u00a0\u00e0\u00a0<\/span>contrata\u00e7\u00e3o<\/span>\u00a0de\u00a0<\/span>jovens<\/span>\u00a0especializados em\u00a0<\/span>internacionaliza\u00e7\u00e3o<\/span><\/strong><\/em><\/li>\n<\/ul>\n
$\"\"$ <\/p>\n<\/section>\n<\/article>\n<\/body><\/html>","protected":false},"excerpt":{"rendered":"
Neste artigo explicamos tudo sobre o probi\u00f3tico Lactobacillus reuteri, conhecido pela sua capacidade de modular a microbiota, produzir compostos antimicrobianos e apoiar a barreira intestinal. Tamb\u00e9m iremos rever as propriedades, tipos\/estirpes mais utilizados, os benef\u00edcios e as chaves de conce\u00e7\u00e3o e avalia\u00e7\u00e3o necess\u00e1rias para os transformar em produtos vi\u00e1veis. Lactobacillus reuteri: propriedades, benef\u00edcios e aplica\u00e7\u00f5es […]<\/p>\n","protected":false},"author":286,"featured_media":189106,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1963],"tags":[],"class_list":["post-189463","post","type-post","status-publish","format-standard","hentry","category-inovacao-tecnologica"],"acf":[],"yoast_head":"\nProbi\u00f3tico Lactobacillus reuteri: para que serve, tipos e benef\u00edcio - AINIA<\/title>\n<meta name=\"description\" content=\"Descubra as propriedades, benef\u00edcios, estirpes e aplica\u00e7\u00f5es do probi\u00f3tico Lactobacillus reuteri, bem como os crit\u00e9rios de conce\u00e7\u00e3o e avalia\u00e7\u00e3o para desenvolver produtos probi\u00f3ticos vi\u00e1veis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ainia.com\/pt\/ainia-news\/probiotico-lactobacillus-reuteri-para-que-serve-tipos-e-beneficio\/\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Probi\u00f3tico Lactobacillus reuteri: para que serve, tipos e benef\u00edcio - 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