{"id":188687,"date":"2026-03-17T14:37:15","date_gmt":"2026-03-17T13:37:15","guid":{"rendered":"https:\/\/www.ainia.com\/?p=188687"},"modified":"2026-03-17T14:37:39","modified_gmt":"2026-03-17T13:37:39","slug":"avancos-biotecnologicos-para-transformar-residuos-vegetais-em-compostos-contra-a-inflamacao-do-colon","status":"publish","type":"post","link":"https:\/\/www.ainia.com\/pt\/ainia-news\/avancos-biotecnologicos-para-transformar-residuos-vegetais-em-compostos-contra-a-inflamacao-do-colon\/","title":{"rendered":"Avan\u00e7os biotecnol\u00f3gicos para transformar res\u00edduos vegetais em compostos contra a inflama\u00e7\u00e3o do c\u00f3lon"},"content":{"rendered":"

No \u00e2mbito do projeto PHARMANOVA II, AINIA desenvolveu novas solu\u00e7\u00f5es biotecnol\u00f3gicas baseadas em res\u00edduos vegetais<\/a> <\/strong>para tratar doen\u00e7as inflamat\u00f3rias do c\u00f3lon, como a colite ulcerosa ou a doen\u00e7a de Crohn. Para tal, foram utilizadas quatro tecnologias-chave: tecnologia in vitro<\/em> baseada em modelos celulares 3D, tecnologias separativas, tecnologias de caracteriza\u00e7\u00e3o qu\u00edmica e tecnologias de liberta\u00e7\u00e3o controlada.<\/p>\n

Um dos principais avan\u00e7os foi a melhoria de uma plataforma celular<\/strong> que identifica, de forma r\u00e1pida e fi\u00e1vel, mol\u00e9culas naturais com potencial terap\u00eautico. Isto permitiu comprovar o efeito anti-inflamat\u00f3rio de extratos vegetais como a rom\u00e3 e o pist\u00e1cio.<\/p>\n

\"AINIA<\/strong><\/h2>\n

Modelos 3D e gut-on-chip que imitam a resposta do c\u00f3lon humano<\/strong><\/h2>\n

No \u00e2mbito deste projeto, a equipa da AINIA desenvolveu modelos celulares avan\u00e7ados<\/strong> a partir de c\u00e9lulas humanas de carcinoma colorretal para estudar o seu mecanismo de a\u00e7\u00e3o. Entre as t\u00e9cnicas desenvolvidas destacam-se as t\u00e9cnicas de cultura 3D<\/strong>, para a gera\u00e7\u00e3o de esferoides intestinais<\/strong>, estruturas celulares tridimensionais que imitam a organiza\u00e7\u00e3o e o comportamento do tecido humano. A partir delas foram criados modelos de c\u00f3lon inflamado em 3D<\/strong>, que permitem avaliar de forma mais representativa a resposta das c\u00e9lulas intestinais a compostos naturais com potencial terap\u00eautico. Em particular, com esta tecnologia foi poss\u00edvel observar a a\u00e7\u00e3o anti-inflamat\u00f3ria de um p\u00f3s-bi\u00f3tico \u2014 composto ben\u00e9fico produzido durante a fermenta\u00e7\u00e3o \u2014 e de extrato de rom\u00e3.<\/p>\n

Al\u00e9m disso, foi utilizada uma tecnologia inovadora conhecida como gut-on-chip<\/em>, <\/strong>um pequeno dispositivo que simula as condi\u00e7\u00f5es do intestino humano. Esta ferramenta permite monitorizar em tempo real como evoluem os processos inflamat\u00f3rios e como os compostos estudados atuam sobre eles.<\/p>\n

Tecnologias mais limpas para obter ingredientes naturais de interesse<\/strong><\/h2>\n

Outra das linhas de trabalho centrou-se na utiliza\u00e7\u00e3o de CO\u2082 supercr\u00edtico, uma tecnologia de extra\u00e7\u00e3o mais sustent\u00e1vel e amiga do ambiente. Gra\u00e7as a este m\u00e9todo, foram obtidas fra\u00e7\u00f5es de rom\u00e3 e pist\u00e1cio mais est\u00e1veis e com maior concentra\u00e7\u00e3o de compostos que podem contribuir para melhorar os processos inflamat\u00f3rios.<\/a><\/strong><\/p>\n

Para analisar estes extratos com precis\u00e3o, a equipa desenvolveu tamb\u00e9m uma t\u00e9cnica que permite medir de forma fi\u00e1vel a presen\u00e7a de tocotrien\u00f3is, um tipo de vitamina E com propriedades antioxidantes e potencial benef\u00edcio face \u00e0 inflama\u00e7\u00e3o.<\/p>\n

Rumo a tratamentos mais eficazes e naturais<\/strong><\/h2>\n

O projeto tamb\u00e9m permitiu conceber um sistema de dupla encapsula\u00e7\u00e3o que protege os compostos naturais durante a digest\u00e3o, garantindo que chegam ao c\u00f3lon, onde devem exercer a sua a\u00e7\u00e3o.<\/p>\n

PHARMANOVA II \u00e9 um projeto apoiado pelo IVACE<\/a>,<\/strong> atrav\u00e9s do Programa FEDER Comunitat Valenciana 2021-2027 financiado pela Uni\u00e3o Europeia, e desenvolvido em colabora\u00e7\u00e3o com as empresas Nova Terra Foods e Monteloeder.<\/p>\n

\"Logo<\/p>\n<\/body><\/html>","protected":false},"excerpt":{"rendered":"

No \u00e2mbito do projeto PHARMANOVA II, AINIA desenvolveu novas solu\u00e7\u00f5es biotecnol\u00f3gicas baseadas em res\u00edduos vegetais para tratar doen\u00e7as inflamat\u00f3rias do c\u00f3lon, como a colite ulcerosa ou a doen\u00e7a de Crohn. Para tal, foram utilizadas quatro tecnologias-chave: tecnologia in vitro baseada em modelos celulares 3D, tecnologias separativas, tecnologias de caracteriza\u00e7\u00e3o qu\u00edmica e tecnologias de liberta\u00e7\u00e3o controlada. […]<\/p>\n","protected":false},"author":198,"featured_media":185213,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1980],"tags":[],"class_list":["post-188687","post","type-post","status-publish","format-standard","hentry","category-comunicados-de-imprensa"],"acf":[],"yoast_head":"\nAINIA desenvolve tecnologias contra a inflama\u00e7\u00e3o do c\u00f3lon - AINIA<\/title>\n<meta name=\"description\" content=\"AINIA alcan\u00e7a avan\u00e7os biotecnol\u00f3gicos para transformar res\u00edduos vegetais em compostos contra a inflama\u00e7\u00e3o do c\u00f3lon\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ainia.com\/pt\/ainia-news\/avancos-biotecnologicos-para-transformar-residuos-vegetais-em-compostos-contra-a-inflamacao-do-colon\/\" 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