[vc_row][vc_column][vc_column_text css=\u201d\u201d]<\/p>\n

A procura de micro-organismos com propriedades funcionais diferenciadoras<\/strong> \u00e9 atualmente uma das principais alavancas de inova\u00e7\u00e3o nos setores alimentar, farmac\u00eautico e biotecnol\u00f3gico. Neste contexto, no projeto BIOPROSPECT<\/strong>, trabalh\u00e1mos na identifica\u00e7\u00e3o, caracteriza\u00e7\u00e3o e valida\u00e7\u00e3o funcional de novas estirpes microbianas atrav\u00e9s de estrat\u00e9gias avan\u00e7adas de bioprospe\u00e7\u00e3o<\/strong>, combinadas com ferramentas tecnol\u00f3gicas que permitem agilizar e otimizar a sua avalia\u00e7\u00e3o.<\/p>\n

O BIOPROSPECT permitiu avan\u00e7ar no conhecimento e na obten\u00e7\u00e3o de bact\u00e9rias \u00e1cido-l\u00e1cticas (BAL)<\/strong> com potencial fermentativo e probi\u00f3tico, bem como desenvolver uma plataforma automatizada para a cribagem e monitoriza\u00e7\u00e3o do crescimento microbiano<\/strong>, claramente orientada para a sua futura aplica\u00e7\u00e3o industrial.<\/p>\n

V\u00eddeo: resultados e abordagem tecnol\u00f3gica do BIOPROSPECT<\/strong><\/a><\/p>\n

Neste v\u00eddeo, apresentamos os principais resultados do projeto e a abordagem tecnol\u00f3gica desenvolvida para identificar e avaliar micro-organismos de interesse a partir de ambientes marinhos profundos e amostras humanas<\/strong>, bem como o seu potencial para gerar novas solu\u00e7\u00f5es biotecnol\u00f3gicas.<\/p>\n

\ufeff<\/span><\/iframe><\/p>\n<h2 data-start=\"1434\" data-end=\"1522\">Bioprospe\u00e7\u00e3o em ambientes diversificados para ampliar a biodiversidade microbiana<\/strong><\/h2>\nNo \u00e2mbito do BIOPROSPECT, a bioprospe\u00e7\u00e3o microbiana foi abordada a partir de duas origens complementares. Por um lado, foram realizadas campanhas de amostragem em fundos marinhos profundos<\/strong>, com o objetivo de identificar g\u00e9neros microbianos ainda pouco explorados e com potencial biotecnol\u00f3gico. Por outro lado, trabalh\u00e1mos com amostras humanas provenientes de lactentes<\/strong>, uma fonte particularmente relevante para o isolamento de bact\u00e9rias \u00e1cido-l\u00e1cticas associadas ao ecossistema intestinal.<\/p>\nA partir destas fontes, foram isoladas mais de 100 estirpes bacterianas<\/strong>, que foram posteriormente submetidas a um processo estruturado de cribagem e sele\u00e7\u00e3o.<\/p>\n<h3 data-start=\"2192\" data-end=\"2262\">Caracteriza\u00e7\u00e3o genot\u00edpica e funcional das estirpes selecionadas<\/strong><\/h3>\nUma parte significativa das estirpes isoladas foi sujeita a uma caracteriza\u00e7\u00e3o genot\u00edpica completa<\/strong>, recorrendo a t\u00e9cnicas de sequencia\u00e7\u00e3o que permitiram obter um perfil gen\u00e9tico detalhado. Esta abordagem possibilitou avaliar a inocuidade de cada micro-organismo<\/strong> e identificar propriedades funcionais de interesse industrial.<\/p>\nDe forma complementar, foi realizada uma caracteriza\u00e7\u00e3o fenot\u00edpica aprofundada<\/strong>, avaliando par\u00e2metros-chave como a toler\u00e2ncia a condi\u00e7\u00f5es adversas, a capacidade fermentativa e o potencial probi\u00f3tico. Estes estudos foram apoiados por ensaios in vitro<\/strong> destinados a avaliar a resist\u00eancia ao tr\u00e2nsito gastrointestinal e \u00e0 fermenta\u00e7\u00e3o col\u00f3nica, bem como a capacidade dos micro-organismos para aderir a modelos epiteliais, fornecendo informa\u00e7\u00e3o relevante sobre o seu potencial probi\u00f3tico.<\/p>\nOs resultados obtidos confirmam que v\u00e1rias das estirpes avaliadas apresentam resist\u00eancia a pH \u00e1cido e a sais biliares<\/strong>, um comportamento fermentativo favor\u00e1vel e uma intera\u00e7\u00e3o eficaz com modelos epiteliais, refor\u00e7ando o seu interesse para aplica\u00e7\u00f5es nas \u00e1reas da alimenta\u00e7\u00e3o e da sa\u00fade.<\/p>\n<h3><img decoding=\"async\" class=\"alignnone wp-image-185788 size-large\" src=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/gastrointestinal-1024x576.jpg\" alt=\"digestores AINIA\" width=\"1024\" height=\"576\" srcset=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/gastrointestinal-1024x576.jpg 1024w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/gastrointestinal-300x169.jpg 300w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/gastrointestinal-768x432.jpg 768w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/gastrointestinal-1536x864.jpg 1536w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/gastrointestinal-2048x1152.jpg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><\/strong><\/h3>\n<h3 data-start=\"3385\" data-end=\"3458\">Plataforma automatizada para a cribagem e monitoriza\u00e7\u00e3o microbiana<\/strong><\/h3>\nComo um dos principais avan\u00e7os tecnol\u00f3gicos do projeto, o BIOPROSPECT permitiu o desenvolvimento de uma plataforma automatizada<\/strong> que possibilita a cribagem em larga escala e a monitoriza\u00e7\u00e3o em tempo real do crescimento microbiano<\/strong> sob diferentes substratos e condi\u00e7\u00f5es experimentais.<\/p>\nEsta ferramenta permitiu otimizar os tempos de avalia\u00e7\u00e3o, melhorar a reprodutibilidade dos ensaios e facilitar a compara\u00e7\u00e3o objetiva entre estirpes, acelerando assim a tomada de decis\u00f5es nos processos de sele\u00e7\u00e3o com vista ao escalonamento e \u00e0 aplica\u00e7\u00e3o industrial.<\/p>\n<h3><img decoding=\"async\" class=\"alignnone wp-image-185767 size-large\" src=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/plataforma-cribado-automatizada-1024x576.jpg\" alt=\"\" width=\"1024\" height=\"576\" srcset=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/plataforma-cribado-automatizada-1024x576.jpg 1024w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/plataforma-cribado-automatizada-300x169.jpg 300w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/plataforma-cribado-automatizada-768x432.jpg 768w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/plataforma-cribado-automatizada.jpg 1200w\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><\/strong><\/h3>\n<h3 data-start=\"4022\" data-end=\"4093\">Valida\u00e7\u00e3o do potencial industrial em matrizes l\u00e1cteas e vegetais<\/strong><\/h3>\nO projeto contou com a colabora\u00e7\u00e3o das empresas ALNUT<\/strong>, DACSA<\/strong> e NATRA<\/strong>, com as quais foram iniciados estudos orientados para a aplica\u00e7\u00e3o industrial<\/strong> das estirpes selecionadas. Neste \u00e2mbito, foi avaliado o potencial fermentativo de estirpes previamente caracterizadas, utilizando leite inteiro como mat\u00e9ria-prima<\/strong>, com o objetivo de desenvolver um iogurte sem necessidade de recorrer a culturas starter adicionais.<\/p>\nEm paralelo, foram realizados ensaios de fermenta\u00e7\u00e3o em matrizes vegetais<\/strong>, incluindo farinhas e outros substratos, abrindo caminho ao desenvolvimento de produtos inovadores adaptados a diferentes mercados e alinhados com as novas tend\u00eancias da alimenta\u00e7\u00e3o e da biotecnologia.<\/p>\n<h3><img decoding=\"async\" class=\"alignnone wp-image-185762 size-large\" src=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/colaboracion-emrpesa-bioprospect-1024x576.jpg\" alt=\"colaboraci\u00f3n empresa\" width=\"1024\" height=\"576\" srcset=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/colaboracion-emrpesa-bioprospect-1024x576.jpg 1024w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/colaboracion-emrpesa-bioprospect-300x169.jpg 300w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/colaboracion-emrpesa-bioprospect-768x432.jpg 768w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/colaboracion-emrpesa-bioprospect.jpg 1200w\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><\/strong><\/h3>\n<h2 data-start=\"4812\" data-end=\"4871\">A bioprospe\u00e7\u00e3o como motor da inova\u00e7\u00e3o biotecnol\u00f3gica<\/strong><\/h2>\nOs resultados do BIOPROSPECT confirmam o valor da bioprospe\u00e7\u00e3o<\/strong> como estrat\u00e9gia para identificar micro-organismos com propriedades diferenciadoras e acelerar a sua transfer\u00eancia para aplica\u00e7\u00f5es reais. A combina\u00e7\u00e3o da biodiversidade microbiana, de ensaios funcionais avan\u00e7ados e de ferramentas automatizadas de cribagem refor\u00e7a a capacidade de gerar solu\u00e7\u00f5es biotecnol\u00f3gicas com impacto industrial<\/strong>.<\/p>\nNa AINIA, estes avan\u00e7os consolidam o nosso posicionamento como parceiro tecnol\u00f3gico<\/strong> para empresas que procuram inovar no desenvolvimento de ingredientes, processos fermentativos e solu\u00e7\u00f5es baseadas em micro-organismos funcionais.<\/p>\nEsta iniciativa contou com o apoio da Conselleria d\u2019Innovaci\u00f3, Ind\u00fastria, Comer\u00e7 i Turisme<\/strong> da Generalitat Valenciana, atrav\u00e9s do IVACE<\/strong>, e com financiamento da Uni\u00e3o Europeia no \u00e2mbito do Programa FEDER Comunitat Valenciana 2021\u20132027<\/strong>, contribuindo para o posicionamento da Comunidade Valenciana no desenvolvimento da biotecnologia baseada em micro-organismos, na inova\u00e7\u00e3o em fermenta\u00e7\u00e3o e na transfer\u00eancia de conhecimento para aplica\u00e7\u00f5es industriais e alimentares de elevado valor acrescentado.<\/p>\n\u00a0<\/p>\n<img decoding=\"async\" class=\"alignnone wp-image-180198 size-large\" src=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/09\/IVACEUEdeclaracion-cs-negro-1-1024x110.png\" alt=\"logo ivace feder 2025 nuevo\" width=\"1024\" height=\"110\" srcset=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/09\/IVACEUEdeclaracion-cs-negro-1-1024x110.png 1024w, https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/09\/IVACEUEdeclaracion-cs-negro-1-300x32.png 300w, https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/09\/IVACEUEdeclaracion-cs-negro-1-768x82.png 768w, https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/09\/IVACEUEdeclaracion-cs-negro-1-1536x164.png 1536w, https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/09\/IVACEUEdeclaracion-cs-negro-1-2048x219.png 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\">[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div><\/body><\/html>","protected":false},"excerpt":{"rendered":"[vc_row][vc_column][vc_column_text css=\u201d\u201d] A procura de micro-organismos com propriedades funcionais diferenciadoras \u00e9 atualmente uma das principais alavancas de inova\u00e7\u00e3o nos setores alimentar, farmac\u00eautico e biotecnol\u00f3gico. Neste contexto, no projeto BIOPROSPECT, trabalh\u00e1mos na identifica\u00e7\u00e3o, caracteriza\u00e7\u00e3o e valida\u00e7\u00e3o funcional de novas estirpes microbianas atrav\u00e9s de estrat\u00e9gias avan\u00e7adas de bioprospe\u00e7\u00e3o, combinadas com ferramentas tecnol\u00f3gicas que permitem agilizar e otimizar […]<\/p>\n","protected":false},"author":401,"featured_media":185776,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1963],"tags":[],"class_list":["post-186295","post","type-post","status-publish","format-standard","hentry","category-inovacao-tecnologica"],"acf":[],"yoast_head":"\n<title>Bioprospe\u00e7\u00e3o para identificar micro-organismos com potencial industrial<\/title>\n<meta name=\"description\" content=\"Bioprospe\u00e7\u00e3o aplicada \u00e0 identifica\u00e7\u00e3o, caracteriza\u00e7\u00e3o e valida\u00e7\u00e3o de 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