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O processo de bioimpress\u00e3o celular<\/strong> em si, ou seja, a forma como as estruturas s\u00e3o criadas pela deposi\u00e7\u00e3o da bio-tinta no suporte, pode ser classificado em tr\u00eas tipos de tecnologias nas quais se baseiam as diferentes bioimpressoras dispon\u00edveis no mercado:<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Bioimpress\u00e3o por extrus\u00e3o, onde a bio-tinta \u00e9 extrudida atrav\u00e9s de injetores formando um filamento cont\u00ednuo;<\/li>\n
Bioimpress\u00e3o drop-on-demand, na qual a bio-tinta \u00e9 colocada atrav\u00e9s de uma \u201cgota discreta\u201d que se empilha para criar a estrutura. Existem tamb\u00e9m diferentes formas de criar a gota (processos t\u00e9rmicos, piezoel\u00e9tricos e assistidos por laser).<\/li>\n
Bioimpress\u00e3o baseada em fotopolimeriza\u00e7\u00e3o, que se baseia na sensibilidade \u00e0 luz de alguns pol\u00edmeros para a sua solidifica\u00e7\u00e3o atrav\u00e9s da luz.
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A bioimpress\u00e3o celular foi inicialmente concebida como uma alternativa \u00e0 cont\u00ednua procura de transplantes de \u00f3rg\u00e3os. Foi demonstrada pela primeira vez pelo Dr. Klebe nos anos 80, atrav\u00e9s da microadi\u00e7\u00e3o de c\u00e9lulas em camadas, utilizando uma impressora convencional Hewlett-Packard (HP). No entanto, os avan\u00e7os tecnol\u00f3gicos que facilitam e aumentam a viabilidade celular ap\u00f3s passar pelos injetores, entre outros fatores, permitiram uma intensifica\u00e7\u00e3o da investiga\u00e7\u00e3o sobre a sua aplicabilidade desde o ano 2000. Gra\u00e7as \u00e0 capacidade de manipula\u00e7\u00e3o espa\u00e7o-temporal de v\u00e1rias c\u00e9lulas, a bioimpress\u00e3o<\/strong> tornou-se num dos sistemas que melhor recria o microambiente celular dos tecidos<\/strong>, imitando assim o comportamento celular em escala laboratorial. A bioimpress\u00e3o 3D de \u00f3rg\u00e3os \u00e9 complexa e a tecnologia ainda precisa de evoluir.<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
Aplica\u00e7\u00e3o da bioimpress\u00e3o 3D nos setores farmac\u00eautico, dermocosm\u00e9tico e alimentar<\/h2>\n
A aplica\u00e7\u00e3o da bioimpress\u00e3o 3D estendeu-se a v\u00e1rios campos para al\u00e9m da medicina regenerativa<\/strong> para reconstru\u00e7\u00e3o de tecidos (por exemplo, c\u00f3rneas, ossos ou cartilagens), tais como:<\/p>\n
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No setor farmac\u00eautico<\/strong>, para estudar o mecanismo de a\u00e7\u00e3o de certas patologias e identificar novos medicamentos, como agentes antitumorais<\/li>\n
No setor dermocosm\u00e9tico<\/strong>, para criar pele e estudar os efeitos de compostos ou f\u00f3rmulas espec\u00edficas.<\/li>\n
Adicionalmente, outro setor com aplica\u00e7\u00f5es potenciais \u00e9 a ind\u00fastria alimentar<\/strong>, que se adequa ao desenvolvimento de ingredientes e produtos com efeitos funcionais. Esta tecnologia permite a cria\u00e7\u00e3o de modelos in vitro mais precisos das fun\u00e7\u00f5es fisiol\u00f3gicas de interesse, bem como a produ\u00e7\u00e3o de carne in vitro, uma das alternativas tecnol\u00f3gicas mais significativas para o fornecimento sustent\u00e1vel de prote\u00ednas. A bioimpress\u00e3o 3D permite a cria\u00e7\u00e3o de andaimes sobre os quais as c\u00e9lulas do tecido muscular s\u00e3o depositadas para posterior cultivo num biorreator.<\/li>\n<\/ul>\n
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Um dos principais desafios futuros da bioimpress\u00e3o 3D \u00e9 a cria\u00e7\u00e3o de \u00f3rg\u00e3os para transplantes. Embora a reprodu\u00e7\u00e3o de uma estrutura celular t\u00e3o complexa tenha sido o seu objetivo inicial, continua a ser uma tarefa dif\u00edcil. No entanto, est\u00e1-se a fazer progressos. Vale a pena destacar que j\u00e1 se discute a bioimpress\u00e3o 4D, onde as c\u00e9lulas utilizadas para criar os tecidos s\u00e3o c\u00e9lulas doadoras. Portanto, prev\u00ea-se que esta tecnologia seja fundamental para a biomedicina personalizada.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
Com base no exposto, consideramos a bioimpress\u00e3o celular como uma tecnologia revolucion\u00e1ria de engenharia de tecidos, que est\u00e1 a tornar o \u201cin vitro\u201d cada vez mais pr\u00f3ximo do \u201cin vivo\u201d<\/strong>.<\/p>\n
TECNOMIFOOD:Desenvolvimento de Modelos Celulares atrav\u00e9s de Bioimpress\u00e3o 3D<\/h2>\n
AINIA, no \u00e2mbito do projeto TECNOMIFOOD, est\u00e1 a trabalhar no desenvolvimento de modelos celulares atrav\u00e9s da bioimpress\u00e3o 3D. Al\u00e9m disso, a utiliza\u00e7\u00e3o de um sistema integrado pr\u00f3prio, que inclui o Digestor Din\u00e2mico de AINIA para a fermenta\u00e7\u00e3o col\u00f3nica e os modelos celulares 3D,<\/strong> permite a recria\u00e7\u00e3o de todo o processo de ingest\u00e3o de produtos: digest\u00e3o gastrointestinal, bioacessibilidade e biodisponibilidade de compostos, imitando a intera\u00e7\u00e3o com a microbiota intestinal, bem como o efeito biol\u00f3gico no tecido alvo. Combinado com as tecnologias \u00f3micas para monitorizar as respostas biol\u00f3gicas (prote\u00f3mica, metagen\u00f3mica e transcript\u00f3mica direcionada), isto constitui um modelo pr\u00e9-cl\u00ednico in vitro vers\u00e1til, robusto e preciso para identificar, selecionar e avaliar ingredientes bioativos e produtos funcionais.<\/p>\n
A Rede TecnomiFood<\/strong> \u00e9 uma rede formada por cinco centros tecnol\u00f3gicos (AINIA, ANFACO, AZTI, CNTA, LEITAT), que visa integrar tecnologias \u00f3micas para facilitar o acesso das empresas a estas tecnologias e otimizar a sua utiliza\u00e7\u00e3o em todas as fases da cadeia de valor no design e avalia\u00e7\u00e3o de ingredientes, nutrac\u00eauticos e alimentos funcionais.<\/p>\n
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[vc_row][vc_column][vc_column_text css=\u201d\u201d]A bioimpress\u00e3o celular 3D \u00e9 uma tecnologia de ponta para criar tecidos vivos, como vasos sangu\u00edneos, ossos, cartilagem ou pele. Baseia-se na tecnologia de manufatura aditiva da impress\u00e3o 3D. Ou seja, as estruturas celulares tridimensionais s\u00e3o geradas adicionando camada ap\u00f3s camada de material, sem a necessidade de um molde. O material adicionado camada por […]<\/p>\n","protected":false},"author":236,"featured_media":174405,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1963],"tags":[],"class_list":["post-174403","post","type-post","status-publish","format-standard","hentry","category-inovacao-tecnologica"],"acf":[],"yoast_head":"\nBioimpress\u00e3o celular 3D, fic\u00e7\u00e3o cient\u00edfica ou realidade?<\/title>\n<meta name=\"description\" content=\"Aplica\u00e7\u00f5es da bioimpress\u00e3o 3D, uma tecnologia que permite a gera\u00e7\u00e3o de estruturas celulares tridimensionais. 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Mi especialidad se centra en el desarrollo de modelos avanzados que simulan el tracto gastrointestinal y la fermentaci\u00f3n col\u00f3nica, as\u00ed como \u00f3rganos diana mediante t\u00e9cnicas como cultivo celular, bioimpresi\u00f3n 3D y \u00f3rganos-on-chip. Doctora en Bioqu\u00edmica y Biolog\u00eda Molecular por la Universitat de Val\u00e8ncia, combino una s\u00f3lida formaci\u00f3n cient\u00edfica con experiencia en gesti\u00f3n y transferencia tecnol\u00f3gica. Colaboro con empresas de los sectores alimentario, cosm\u00e9tico y nutrac\u00e9utico para impulsar soluciones innovadoras basadas en evidencia cient\u00edfica. He participado en proyectos nacionales e internacionales como PHARMANOVA, MEAT4FUTURE y PATHWAY-27, y soy miembro activo de redes como INFOGEST, INFOGUT y Food4Life. Adem\u00e1s, imparto formaci\u00f3n especializada en congresos y jornadas sectoriales, contribuyendo a la divulgaci\u00f3n cient\u00edfica y al avance de la investigaci\u00f3n aplicada.","sameAs":["https:\/\/www.ainia.com\/contactar-lidia-tomas\/","=https:\/\/www.linkedin.com\/public-profile\/settings?lipi=urnlipaged_flagship3_profile_self_edit_contact-infoSUVPYk6QOSvsEj2ZXWSXQ"],"url":"https:\/\/www.ainia.com\/pt\/ainia-news\/author\/lidia-tomas-cobos\/"}]}},"_links":{"self":[{"href":"https:\/\/www.ainia.com\/pt\/wp-json\/wp\/v2\/posts\/174403","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ainia.com\/pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ainia.com\/pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ainia.com\/pt\/wp-json\/wp\/v2\/users\/236"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ainia.com\/pt\/wp-json\/wp\/v2\/comments?post=174403"}],"version-history":[{"count":2,"href":"https:\/\/www.ainia.com\/pt\/wp-json\/wp\/v2\/posts\/174403\/revisions"}],"predecessor-version":[{"id":174409,"href":"https:\/\/www.ainia.com\/pt\/wp-json\/wp\/v2\/posts\/174403\/revisions\/174409"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ainia.com\/pt\/wp-json\/wp\/v2\/media\/174405"}],"wp:attachment":[{"href":"https:\/\/www.ainia.com\/pt\/wp-json\/wp\/v2\/media?parent=174403"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ainia.com\/pt\/wp-json\/wp\/v2\/categories?post=174403"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ainia.com\/pt\/wp-json\/wp\/v2\/tags?post=174403"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}