{"id":188684,"date":"2026-03-17T14:38:28","date_gmt":"2026-03-17T13:38:28","guid":{"rendered":"https:\/\/www.ainia.com\/?p=188684"},"modified":"2026-03-17T14:38:28","modified_gmt":"2026-03-17T13:38:28","slug":"avancees-biotechnologiques-pour-transformer-des-residus-vegetaux-en-composes-contre-linflammation-du-colon","status":"publish","type":"post","link":"https:\/\/www.ainia.com\/fr\/ainia-news\/avancees-biotechnologiques-pour-transformer-des-residus-vegetaux-en-composes-contre-linflammation-du-colon\/","title":{"rendered":"Avanc\u00e9es biotechnologiques pour transformer des r\u00e9sidus v\u00e9g\u00e9taux en compos\u00e9s contre l\u2019inflammation du c\u00f4lon"},"content":{"rendered":"

Dans le cadre du projet PHARMANOVA II, AINIA a d\u00e9velopp\u00e9 de nouvelles solutions biotechnologiques bas\u00e9es sur des r\u00e9sidus v\u00e9g\u00e9taux<\/a><\/strong> pour traiter des maladies inflammatoires du c\u00f4lon, telles que la colite ulc\u00e9reuse ou la maladie de Crohn. Pour cela, quatre technologies cl\u00e9s ont \u00e9t\u00e9 utilis\u00e9es : la technologie in vitro<\/em> bas\u00e9e sur des mod\u00e8les cellulaires 3D, des technologies s\u00e9paratives, des technologies de caract\u00e9risation chimique et des technologies de lib\u00e9ration contr\u00f4l\u00e9e.<\/p>\n

L\u2019une des principales avanc\u00e9es a \u00e9t\u00e9 l\u2019am\u00e9lioration d\u2019une plateforme cellulaire<\/strong> capable d\u2019identifier, de mani\u00e8re rapide et fiable, des mol\u00e9cules naturelles ayant un potentiel th\u00e9rapeutique. Cela a permis de v\u00e9rifier l\u2019effet anti-inflammatoire d\u2019extraits v\u00e9g\u00e9taux tels que la grenade et la pistache.<\/p>\n

\"AINIA<\/strong><\/h2>\n

Mod\u00e8les 3D et gut-on-chip<\/em> qui imitent la r\u00e9ponse du c\u00f4lon humain<\/strong><\/h2>\n

Dans le cadre de ce projet, l\u2019\u00e9quipe d\u2019AINIA a d\u00e9velopp\u00e9 des mod\u00e8les cellulaires avanc\u00e9s<\/strong> \u00e0 partir de cellules humaines de carcinome colorectal afin d\u2019\u00e9tudier leur m\u00e9canisme d\u2019action. Parmi les techniques d\u00e9velopp\u00e9es, se distinguent les techniques de culture 3D<\/strong>, permettant la g\u00e9n\u00e9ration de sph\u00e9ro\u00efdes intestinaux<\/strong>, des structures cellulaires tridimensionnelles qui imitent l\u2019organisation et le comportement du tissu humain. \u00c0 partir de celles-ci, des mod\u00e8les de c\u00f4lon inflamm\u00e9 en 3D<\/strong> ont \u00e9t\u00e9 cr\u00e9\u00e9s, permettant d\u2019\u00e9valuer de mani\u00e8re plus repr\u00e9sentative la r\u00e9ponse des cellules intestinales \u00e0 des compos\u00e9s naturels \u00e0 potentiel th\u00e9rapeutique. En particulier, cette technologie a permis d\u2019observer l\u2019action anti-inflammatoire d\u2019un postbiotique \u2014 compos\u00e9 b\u00e9n\u00e9fique produit lors de la fermentation \u2014 ainsi que d\u2019un extrait de grenade.<\/p>\n

En outre, une technologie innovante connue sous le nom de gut-on-chip<\/em><\/strong> a \u00e9t\u00e9 utilis\u00e9e, un petit dispositif qui simule les conditions de l\u2019intestin humain. Cet outil permet de surveiller en temps r\u00e9el l\u2019\u00e9volution des processus inflammatoires et la mani\u00e8re dont les compos\u00e9s \u00e9tudi\u00e9s agissent sur ceux-ci.<\/p>\n

Des technologies plus propres pour obtenir des ingr\u00e9dients naturels d\u2019int\u00e9r\u00eat<\/strong><\/h2>\n

Une autre ligne de travail s\u2019est concentr\u00e9e sur l\u2019utilisation du CO\u2082 supercritique, une technologie d\u2019extraction plus durable et respectueuse de l\u2019environnement. Gr\u00e2ce \u00e0 cette m\u00e9thode, des fractions de grenade et de pistache plus stables ont \u00e9t\u00e9 obtenues, avec une concentration plus \u00e9lev\u00e9e de compos\u00e9s susceptibles de contribuer \u00e0 am\u00e9liorer les processus inflammatoires.<\/a><\/strong><\/p>\n

Pour analyser ces extraits avec pr\u00e9cision, l\u2019\u00e9quipe a \u00e9galement d\u00e9velopp\u00e9 une technique permettant de mesurer de mani\u00e8re fiable la pr\u00e9sence de tocotri\u00e9nols, un type de vitamine E aux propri\u00e9t\u00e9s antioxydantes et pr\u00e9sentant un potentiel b\u00e9n\u00e9fice contre l\u2019inflammation.<\/p>\n

Vers des traitements plus efficaces et plus naturels<\/strong><\/h2>\n

Le projet a \u00e9galement permis de concevoir un syst\u00e8me de double encapsulation qui prot\u00e8ge les compos\u00e9s naturels pendant la digestion, garantissant qu\u2019ils atteignent le c\u00f4lon, o\u00f9 ils doivent exercer leur action.<\/p>\n

PHARMANOVA II est un projet soutenu par IVACE<\/a>,<\/strong> dans le cadre du Programme FEDER Comunitat Valenciana 2021-2027 financ\u00e9 par l\u2019Union europ\u00e9enne, et d\u00e9velopp\u00e9 en collaboration avec les entreprises Nova Terra Foods et Monteloeder.<\/p>\n

\"Logo<\/p>\n<\/body><\/html>","protected":false},"excerpt":{"rendered":"

Dans le cadre du projet PHARMANOVA II, AINIA a d\u00e9velopp\u00e9 de nouvelles solutions biotechnologiques bas\u00e9es sur des r\u00e9sidus v\u00e9g\u00e9taux pour traiter des maladies inflammatoires du c\u00f4lon, telles que la colite ulc\u00e9reuse ou la maladie de Crohn. Pour cela, quatre technologies cl\u00e9s ont \u00e9t\u00e9 utilis\u00e9es : la technologie in vitro bas\u00e9e sur des mod\u00e8les cellulaires 3D, […]<\/p>\n","protected":false},"author":198,"featured_media":185211,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1978],"tags":[],"class_list":["post-188684","post","type-post","status-publish","format-standard","hentry","category-communiques-de-presse"],"acf":[],"yoast_head":"\nAINIA d\u00e9veloppe des technologies contre l\u2019inflammation du c\u00f4lon - AINIA<\/title>\n<meta name=\"description\" content=\"AINIA r\u00e9alise des avanc\u00e9es biotechnologiques pour transformer des r\u00e9sidus v\u00e9g\u00e9taux en compos\u00e9s contre l\u2019inflammation du c\u00f4lon\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link 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