[vc_row][vc_column][vc_column_text css=\u201d\u201d]La recherche de micro-organismes pr\u00e9sentant des propri\u00e9t\u00e9s fonctionnelles diff\u00e9renciantes<\/strong> constitue aujourd\u2019hui l\u2019un des principaux leviers d\u2019innovation dans les secteurs alimentaire, pharmaceutique et biotechnologique. Dans ce contexte, le projet BIOPROSPECT<\/strong> s\u2019est concentr\u00e9 sur l\u2019identification, la caract\u00e9risation et la validation fonctionnelle de nouvelles souches microbiennes \u00e0 travers des strat\u00e9gies avanc\u00e9es de bioprospection<\/strong>, combin\u00e9es \u00e0 des outils technologiques permettant d\u2019acc\u00e9l\u00e9rer et d\u2019optimiser leur \u00e9valuation.<\/p>\n

BIOPROSPECT a permis d\u2019approfondir les connaissances et d\u2019isoler des bact\u00e9ries lactiques (BAL)<\/strong> pr\u00e9sentant un potentiel fermentaire et probiotique, ainsi que de d\u00e9velopper une plateforme automatis\u00e9e pour le criblage et le suivi de la croissance microbienne<\/strong>, clairement orient\u00e9e vers une future application industrielle.<\/p>\n

Vid\u00e9o : r\u00e9sultats et approche technologique de BIOPROSPECT<\/strong><\/a><\/p>\n

Cette vid\u00e9o pr\u00e9sente les principaux r\u00e9sultats du projet et l\u2019approche technologique d\u00e9velopp\u00e9e pour identifier et \u00e9valuer des micro-organismes d\u2019int\u00e9r\u00eat issus d\u2019environnements marins profonds et d\u2019\u00e9chantillons humains<\/strong>, ainsi que leur potentiel pour g\u00e9n\u00e9rer de nouvelles solutions biotechnologiques.<\/p>\n

\ufeff<\/span><\/iframe><\/p>\n<h2 data-start=\"1551\" data-end=\"1649\">Bioprospection dans des environnements diversifi\u00e9s pour \u00e9largir la biodiversit\u00e9 microbienne<\/strong><\/h2>\nDans BIOPROSPECT, la bioprospection microbienne a \u00e9t\u00e9 abord\u00e9e \u00e0 partir de deux sources compl\u00e9mentaires. D\u2019une part, des campagnes d\u2019\u00e9chantillonnage ont \u00e9t\u00e9 men\u00e9es dans les fonds marins profonds<\/strong>, dans le but d\u2019identifier des genres microbiens encore peu explor\u00e9s et pr\u00e9sentant un potentiel biotechnologique. D\u2019autre part, des \u00e9chantillons humains provenant de nourrissons<\/strong> ont \u00e9t\u00e9 \u00e9tudi\u00e9s, constituant une source particuli\u00e8rement pertinente pour l\u2019isolement de bact\u00e9ries lactiques associ\u00e9es \u00e0 l\u2019\u00e9cosyst\u00e8me intestinal.<\/p>\n\u00c0 partir de ces sources, plus de 100 souches bact\u00e9riennes<\/strong> ont \u00e9t\u00e9 isol\u00e9es et soumises \u00e0 un processus structur\u00e9 de criblage et de s\u00e9lection.<\/p>\n<h3 data-start=\"2326\" data-end=\"2403\">Caract\u00e9risation g\u00e9notypique et fonctionnelle des souches s\u00e9lectionn\u00e9es<\/strong><\/h3>\nUne part significative des souches isol\u00e9es a fait l\u2019objet d\u2019une caract\u00e9risation g\u00e9notypique compl\u00e8te<\/strong>, \u00e0 l\u2019aide de techniques de s\u00e9quen\u00e7age, permettant d\u2019obtenir un profil g\u00e9n\u00e9tique d\u00e9taill\u00e9. Cette approche a permis d\u2019\u00e9valuer l\u2019innocuit\u00e9 de chaque micro-organisme<\/strong> et d\u2019identifier des propri\u00e9t\u00e9s fonctionnelles d\u2019int\u00e9r\u00eat industriel.<\/p>\nEn compl\u00e9ment, une caract\u00e9risation ph\u00e9notypique approfondie<\/strong> a \u00e9t\u00e9 r\u00e9alis\u00e9e, en \u00e9valuant des param\u00e8tres cl\u00e9s tels que la tol\u00e9rance \u00e0 des conditions d\u00e9favorables, la capacit\u00e9 fermentaire et le potentiel probiotique. Ces \u00e9tudes ont \u00e9t\u00e9 appuy\u00e9es par des essais in vitro<\/strong> visant \u00e0 \u00e9valuer la r\u00e9sistance au transit gastro-intestinal et \u00e0 la fermentation colique, ainsi que la capacit\u00e9 des micro-organismes \u00e0 adh\u00e9rer \u00e0 des mod\u00e8les \u00e9pith\u00e9liaux, fournissant des informations pertinentes sur leur potentiel probiotique.<\/p>\nLes r\u00e9sultats obtenus confirment que plusieurs des souches \u00e9valu\u00e9es pr\u00e9sentent une r\u00e9sistance au pH acide et aux sels biliaires<\/strong>, un comportement fermentaire favorable et une interaction efficace avec des mod\u00e8les \u00e9pith\u00e9liaux, renfor\u00e7ant ainsi leur int\u00e9r\u00eat pour des applications dans les domaines de l\u2019alimentation et de la sant\u00e9.<\/p>\n<h3><img decoding=\"async\" class=\"alignnone wp-image-185788 size-large\" src=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/gastrointestinal-1024x576.jpg\" alt=\"digestores AINIA\" width=\"1024\" height=\"576\" srcset=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/gastrointestinal-1024x576.jpg 1024w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/gastrointestinal-300x169.jpg 300w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/gastrointestinal-768x432.jpg 768w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/gastrointestinal-1536x864.jpg 1536w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/gastrointestinal-2048x1152.jpg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><\/strong><\/h3>\n<h3 data-start=\"3602\" data-end=\"3670\">Plateforme automatis\u00e9e pour le criblage et le suivi microbien<\/strong><\/h3>\nParmi les avanc\u00e9es technologiques majeures du projet, BIOPROSPECT a permis de d\u00e9velopper une plateforme automatis\u00e9e<\/strong> capable de r\u00e9aliser un criblage \u00e0 haut d\u00e9bit et un suivi en temps r\u00e9el de la croissance microbienne<\/strong> sous diff\u00e9rents substrats et conditions exp\u00e9rimentales.<\/p>\nCet outil a permis d\u2019optimiser les d\u00e9lais d\u2019\u00e9valuation, d\u2019am\u00e9liorer la reproductibilit\u00e9 des essais et de faciliter la comparaison objective entre les souches, acc\u00e9l\u00e9rant ainsi la prise de d\u00e9cision dans les processus de s\u00e9lection en vue de leur mont\u00e9e en \u00e9chelle et de leur application industrielle.<\/p>\n<h3><img decoding=\"async\" class=\"alignnone wp-image-185767 size-large\" src=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/plataforma-cribado-automatizada-1024x576.jpg\" alt=\"\" width=\"1024\" height=\"576\" srcset=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/plataforma-cribado-automatizada-1024x576.jpg 1024w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/plataforma-cribado-automatizada-300x169.jpg 300w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/plataforma-cribado-automatizada-768x432.jpg 768w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/plataforma-cribado-automatizada.jpg 1200w\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><\/strong><\/h3>\n<h3 data-start=\"4258\" data-end=\"4340\">Validation du potentiel industriel dans des matrices laiti\u00e8res et v\u00e9g\u00e9tales<\/strong><\/h3>\nLe projet a \u00e9t\u00e9 men\u00e9 en collaboration avec les entreprises ALNUT<\/strong>, DACSA<\/strong> et NATRA<\/strong>, avec lesquelles des \u00e9tudes ont \u00e9t\u00e9 initi\u00e9es afin d\u2019\u00e9valuer le potentiel d\u2019application industrielle<\/strong> des souches s\u00e9lectionn\u00e9es. Dans ce cadre, la capacit\u00e9 fermentaire de souches pr\u00e9alablement caract\u00e9ris\u00e9es a \u00e9t\u00e9 \u00e9valu\u00e9e en utilisant du lait entier comme mati\u00e8re premi\u00e8re<\/strong>, dans l\u2019objectif de d\u00e9velopper un yaourt sans recours \u00e0 des ferments starters suppl\u00e9mentaires.<\/p>\nEn parall\u00e8le, des essais de fermentation ont \u00e9t\u00e9 r\u00e9alis\u00e9s dans des matrices v\u00e9g\u00e9tales<\/strong>, incluant des farines et d\u2019autres substrats, ouvrant la voie au d\u00e9veloppement de produits innovants adapt\u00e9s \u00e0 diff\u00e9rents march\u00e9s et en phase avec les nouvelles tendances de l\u2019alimentation et de la biotechnologie.<\/p>\n<h3><img decoding=\"async\" class=\"alignnone wp-image-185762 size-large\" src=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/colaboracion-emrpesa-bioprospect-1024x576.jpg\" alt=\"colaboraci\u00f3n empresa\" width=\"1024\" height=\"576\" srcset=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/colaboracion-emrpesa-bioprospect-1024x576.jpg 1024w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/colaboracion-emrpesa-bioprospect-300x169.jpg 300w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/colaboracion-emrpesa-bioprospect-768x432.jpg 768w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/colaboracion-emrpesa-bioprospect.jpg 1200w\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><\/strong><\/h3>\n<h2 data-start=\"5118\" data-end=\"5188\">La bioprospection comme moteur de l\u2019innovation biotechnologique<\/strong><\/h2>\nLes r\u00e9sultats de BIOPROSPECT confirment la valeur de la bioprospection<\/strong> comme strat\u00e9gie permettant d\u2019identifier des micro-organismes aux propri\u00e9t\u00e9s diff\u00e9renciantes et d\u2019acc\u00e9l\u00e9rer leur transfert vers des applications concr\u00e8tes. La combinaison de la biodiversit\u00e9 microbienne, d\u2019essais fonctionnels avanc\u00e9s et d\u2019outils automatis\u00e9s de criblage renforce la capacit\u00e9 \u00e0 g\u00e9n\u00e9rer des solutions biotechnologiques \u00e0 impact industriel<\/strong>.<\/p>\nChez AINIA, ces avanc\u00e9es consolident notre positionnement en tant que partenaire technologique<\/strong> pour les entreprises souhaitant innover dans le d\u00e9veloppement d\u2019ingr\u00e9dients, de proc\u00e9d\u00e9s fermentaires et de solutions bas\u00e9es sur des micro-organismes fonctionnels.<\/p>\nCette initiative a b\u00e9n\u00e9fici\u00e9 du soutien de la Conselleria d\u2019Innovaci\u00f3, Ind\u00fastria, Comer\u00e7 i Turisme<\/strong> de la Generalitat Valenciana, par l\u2019interm\u00e9diaire de l\u2019IVACE<\/strong>, et d\u2019un cofinancement de l\u2019Union europ\u00e9enne via le programme FEDER Comunitat Valenciana 2021\u20132027<\/strong>, contribuant ainsi au positionnement de la Communaut\u00e9 valencienne dans le d\u00e9veloppement de la biotechnologie bas\u00e9e sur les micro-organismes, l\u2019innovation en fermentation et le transfert de connaissances vers des applications industrielles et alimentaires \u00e0 forte valeur ajout\u00e9e.<\/p>\n\u00a0<\/p>\n<img decoding=\"async\" class=\"alignnone wp-image-180198 size-large\" src=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/09\/IVACEUEdeclaracion-cs-negro-1-1024x110.png\" alt=\"logo ivace feder 2025 nuevo\" width=\"1024\" height=\"110\" srcset=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/09\/IVACEUEdeclaracion-cs-negro-1-1024x110.png 1024w, https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/09\/IVACEUEdeclaracion-cs-negro-1-300x32.png 300w, https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/09\/IVACEUEdeclaracion-cs-negro-1-768x82.png 768w, https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/09\/IVACEUEdeclaracion-cs-negro-1-1536x164.png 1536w, https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/09\/IVACEUEdeclaracion-cs-negro-1-2048x219.png 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\">[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div><\/body><\/html>","protected":false},"excerpt":{"rendered":"[vc_row][vc_column][vc_column_text css=\u201d\u201d]La recherche de micro-organismes pr\u00e9sentant des propri\u00e9t\u00e9s fonctionnelles diff\u00e9renciantes constitue aujourd\u2019hui l\u2019un des principaux leviers d\u2019innovation dans les secteurs alimentaire, pharmaceutique et biotechnologique. Dans ce contexte, le projet BIOPROSPECT s\u2019est concentr\u00e9 sur l\u2019identification, la caract\u00e9risation et la validation fonctionnelle de nouvelles souches microbiennes \u00e0 travers des strat\u00e9gies avanc\u00e9es de bioprospection, combin\u00e9es \u00e0 des outils […]<\/p>\n","protected":false},"author":401,"featured_media":185774,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1976],"tags":[],"class_list":["post-186292","post","type-post","status-publish","format-standard","hentry","category-innovation-technologique"],"acf":[],"yoast_head":"\n<title>Bioprospection pour identifier des micro-organismes \u00e0 potentiel industriel<\/title>\n<meta name=\"description\" content=\"Bioprospection: identification, caract\u00e9risation et validation de micro-organismes \u00e0 potentiel industriel pour les secteurs alimentaire et 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