{"id":184094,"date":"2025-11-06T16:53:59","date_gmt":"2025-11-06T14:53:59","guid":{"rendered":"https:\/\/www.ainia.com\/?p=184094"},"modified":"2025-11-28T09:48:57","modified_gmt":"2025-11-28T08:48:57","slug":"validation-composes-bioactifs-les-5-etapes-de-la-digestion","status":"publish","type":"post","link":"https:\/\/www.ainia.com\/fr\/ainia-news\/validation-composes-bioactifs-les-5-etapes-de-la-digestion\/","title":{"rendered":"Validation scientifique des compos\u00e9s bioactifs: les 5 \u00e9tapes de la digestion"},"content":{"rendered":"<html><body><div class=\"wpb-content-wrapper\"><p><span data-contrast=\"none\"><span class=\"TextRun SCXW41880406 BCX8\" lang=\"ES-ES\" xml:lang=\"ES-ES\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW41880406 BCX8\"><span class=\"TextRun SCXW194446391 BCX8\" lang=\"ES-ES\" xml:lang=\"ES-ES\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW194446391 BCX8\"><span class=\"TextRun SCXW1005685 BCX8\" lang=\"ES-ES\" xml:lang=\"ES-ES\" data-contrast=\"auto\"><span class=\"NormalTextRun SpellingErrorV2Themed SCXW1005685 BCX8\">[vc_row][vc_column][vc_column_text css=\u201d\u201d]<\/span><\/span><\/span><\/span><\/span><\/span><\/span><span data-contrast=\"auto\">Comprendre, \u00e9valuer et d\u00e9montrer le m\u00e9canisme d\u2019action des ingr\u00e9dients fonctionnels est essentiel pour les entreprises du secteur. La soci\u00e9t\u00e9 se tourne de plus en plus vers ces compos\u00e9s pour compl\u00e9ter son alimentation, mais il ne suffit pas de les incorporer dans une formulation. Leur inclusion doit \u00eatre justifi\u00e9e selon des crit\u00e8res scientifiques rigoureux : ils doivent \u00eatre soigneusement s\u00e9lectionn\u00e9s et appuy\u00e9s par des travaux solides de recherche, de d\u00e9veloppement et de validation de l\u2019effet fonctionnel qui leur est attribu\u00e9.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<h2 aria-level=\"3\"><b><span data-contrast=\"none\">Comment un ingr\u00e9dient se comporte-t-il dans le syst\u00e8me digestif ?<\/span><\/b><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"134245418\":true,\"134245529\":true,\"335551550\":1,\"335551620\":1,\"335559738\":281,\"335559739\":281}'>\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Lorsqu\u2019un aliment ou un compl\u00e9ment est ing\u00e9r\u00e9, ses <\/span><b><span data-contrast=\"auto\">ingr\u00e9dients actifs<\/span><\/b><span data-contrast=\"auto\"> doivent parcourir un trajet complexe \u00e0 travers le syst\u00e8me digestif. Tout au long de ce processus, ils peuvent subir des transformations chimiques, interagir avec les enzymes digestives, \u00eatre influenc\u00e9s par le pH ou entrer en contact avec le microbiote intestinal.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Il est donc essentiel de d\u00e9terminer :<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<ul>\n<li><span data-contrast=\"auto\">Si l\u2019ingr\u00e9dient r\u00e9siste aux conditions digestives ou s\u2019il se d\u00e9grade avant d\u2019exercer son effet.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/li>\n<li><span data-contrast=\"auto\">Sous quelle forme il atteint l\u2019intestin et s\u2019il est biodisponible, c\u2019est-\u00e0-dire absorbable.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/li>\n<li><span data-contrast=\"auto\">Quel impact il a sur le <a href=\"https:\/\/www.ainia.com\/fr\/ainia-news\/quel-est-le-role-du-microbiote-intestinal-dans-le-developpement-de-lobesite\/\"><strong>microbiote intestinal<\/strong><\/a> et s\u2019il g\u00e9n\u00e8re des m\u00e9tabolites bioactifs.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/li>\n<\/ul>\n<p><span data-contrast=\"auto\">Ces connaissances permettent de concevoir des produits plus efficaces et de justifier objectivement les b\u00e9n\u00e9fices revendiqu\u00e9s.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<h2 aria-level=\"2\"><b><span data-contrast=\"none\">Les \u00e9tapes de la digestion<\/span><\/b><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"134245418\":true,\"134245529\":true,\"335551550\":1,\"335551620\":1,\"335559738\":299,\"335559739\":299}'>\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Le syst\u00e8me digestif humain se divise en plusieurs <\/span><b><span data-contrast=\"auto\">\u00e9tapes de la digestion<\/span><\/b><span data-contrast=\"auto\">, chacune pr\u00e9sentant des conditions tr\u00e8s diff\u00e9rentes susceptibles d\u2019influencer le comportement d\u2019un <\/span><b><span data-contrast=\"auto\">ingr\u00e9dient actif<\/span><\/b><span data-contrast=\"auto\">.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<h3 aria-level=\"3\"><b><span data-contrast=\"none\"><img decoding=\"async\" class=\"alignnone size-large wp-image-184095\" src=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/11\/processus-digestif-1024x680.png\" alt=\"Les 5 \u00e9tapes de la digestion \" width=\"1024\" height=\"680\" srcset=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/11\/processus-digestif-1024x680.png 1024w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/11\/processus-digestif-300x199.png 300w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/11\/processus-digestif-768x510.png 768w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/11\/processus-digestif.png 1280w\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><\/span><\/b><strong>Phase orale : les premi\u00e8res actions enzymatiques\u00a0<\/strong><\/h3>\n<p><span data-contrast=\"auto\">La digestion commence dans la bouche, lors de la phase orale. Les dents broient les aliments en particules plus petites, facilitant leur traitement ult\u00e9rieur. Parall\u00e8lement, les <strong><a href=\"https:\/\/www.ainia.com\/fr\/ainia-news\/fonction-de-la-cavite-buccale-dans-le-systeme-digestif-limportance-des-glandes-salivaires\/\">glandes salivaires<\/a><\/strong> jouent un r\u00f4le cl\u00e9 en s\u00e9cr\u00e9tant des enzymes telles que l\u2019amylase salivaire, qui amorce la d\u00e9composition des glucides complexes.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Une fois bien mastiqu\u00e9 et m\u00e9lang\u00e9 \u00e0 la salive, l\u2019aliment devient le bol alimentaire, qui descend par l\u2019\u0153sophage jusqu\u2019\u00e0 l\u2019estomac, donnant lieu \u00e0 la phase gastrique.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<h3 aria-level=\"3\"><strong>Phase gastrique\u00a0<\/strong><\/h3>\n<p><span data-contrast=\"auto\">Lorsque le bol alimentaire atteint l\u2019estomac, d\u00e9bute la phase gastrique, caract\u00e9ris\u00e9e par un environnement hautement acide. Les aliments se m\u00e9langent alors aux sucs gastriques, une combinaison d\u2019acide chlorhydrique et d\u2019enzymes digestives, notamment la pepsine, responsable de la d\u00e9gradation des prot\u00e9ines en fragments plus petits.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Cette phase remplit plusieurs fonctions essentielles :<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"20\" data-list-defn-props='{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}' data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">D\u00e9nature les prot\u00e9ines, facilitant leur digestion.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"20\" data-list-defn-props='{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}' data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Active des enzymes sp\u00e9cifiques.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"20\" data-list-defn-props='{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}' data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">\u00c9limine les micro-organismes pathog\u00e8nes gr\u00e2ce \u00e0 son faible pH.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/li>\n<\/ul>\n<p><span data-contrast=\"auto\">La dur\u00e9e de cette \u00e9tape varie entre 2 et 4 heures selon le type d\u2019aliment ing\u00e9r\u00e9 (les prot\u00e9ines, par exemple, n\u00e9cessitent plus de temps que les glucides simples).<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Le r\u00e9sultat est un m\u00e9lange semi-liquide appel\u00e9 chyme, qui est progressivement lib\u00e9r\u00e9 dans l\u2019intestin gr\u00eale pour poursuivre les <\/span><b><span data-contrast=\"auto\">\u00e9tapes de la digestion<\/span><\/b><span data-contrast=\"auto\">.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<h3 aria-level=\"3\"><strong>Phase intestinale : absorption et biodisponibilit\u00e9\u00a0<\/strong><\/h3>\n<p><span data-contrast=\"auto\">Au cours de la phase intestinale, le chyme passe dans l\u2019intestin gr\u00eale, o\u00f9 se d\u00e9roule la majeure partie de la digestion et de l\u2019absorption des nutriments. C\u2019est \u00e9galement l\u2019\u00e9tape la plus appropri\u00e9e pour \u00e9tudier l\u2019absorption et \u00e9valuer les effets potentiels d\u2019un <\/span><b><span data-contrast=\"auto\">ingr\u00e9dient actif<\/span><\/b><span data-contrast=\"auto\"> ou fonctionnel.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Cette \u00e9tape des <\/span><b><span data-contrast=\"auto\">\u00e9tapes de la digestion<\/span><\/b><span data-contrast=\"auto\"> est soutenue par l\u2019action combin\u00e9e des enzymes pancr\u00e9atiques et des sels biliaires, qui d\u00e9composent les graisses, les prot\u00e9ines et les glucides en mol\u00e9cules plus simples, pr\u00eates \u00e0 \u00eatre absorb\u00e9es par l\u2019organisme.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Pendant cette phase :<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"21\" data-list-defn-props='{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}' data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Se d\u00e9roule la digestion enzymatique la plus intense.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"21\" data-list-defn-props='{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}' data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Les vitamines, min\u00e9raux, acides amin\u00e9s, acides gras et sucres simples sont absorb\u00e9s.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"21\" data-list-defn-props='{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}' data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">L\u2019intestin r\u00e9gule la biodisponibilit\u00e9 des ingr\u00e9dients actifs ou fonctionnels.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/li>\n<\/ul>\n<p><span data-contrast=\"auto\">Cette phase dure entre 4 et 6 heures, selon le type d\u2019aliment et l\u2019\u00e9tat physiologique de la personne.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<h3 aria-level=\"3\"><strong>Phase colique : interaction avec le microbiote et \u00e9limination finale\u00a0<\/strong><\/h3>\n<p><span data-contrast=\"auto\">Apr\u00e8s l\u2019absorption de la majorit\u00e9 des nutriments dans l\u2019intestin gr\u00eale, le mat\u00e9riel non dig\u00e9r\u00e9 passe dans le c\u00f4lon, o\u00f9 d\u00e9bute la phase colique. D\u2019un point de vue scientifique, cette \u00e9tape est cruciale pour d\u00e9terminer si un <\/span><b><span data-contrast=\"auto\">ingr\u00e9dient actif<\/span><\/b><span data-contrast=\"auto\"> poss\u00e8de un effet pr\u00e9biotique, s\u2019il module le microbiote ou s\u2019il g\u00e9n\u00e8re des m\u00e9tabolites b\u00e9n\u00e9fiques.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Ces effets peuvent \u00eatre \u00e9tudi\u00e9s de mani\u00e8re contr\u00f4l\u00e9e gr\u00e2ce \u00e0 des <\/span><strong><a href=\"https:\/\/www.ainia.com\/fr\/essais-en-digesteur-dynamique-in-vitro-bioaccessibilite-et-essais-en-culture-cellulaire-biodisponibilite\/\">mod\u00e8les de simulation gastro-intestinale<\/a><\/strong><span data-contrast=\"auto\">, qui permettent de reproduire fid\u00e8lement et de mani\u00e8re compl\u00e8te les <\/span><b><span data-contrast=\"auto\">\u00e9tapes de la digestion<\/span><\/b><span data-contrast=\"auto\">, fournissant des informations pr\u00e9cises sur l\u2019impact des ingr\u00e9dients sur le microbiote et son m\u00e9tabolisme.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Cette phase comprend deux processus principaux : la fermentation microbienne et l\u2019\u00e9limination.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Dans le c\u00f4lon :<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<ul>\n<li><span data-contrast=\"auto\">L\u2019eau et certains min\u00e9raux r\u00e9siduels sont absorb\u00e9s, contribuant \u00e0 la compaction du contenu intestinal.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/li>\n<li><span data-contrast=\"auto\">Le microbiote intestinal agit sur les compos\u00e9s non dig\u00e9r\u00e9s, g\u00e9n\u00e9rant des m\u00e9tabolites tels que les acides gras \u00e0 cha\u00eene courte (AGCC), qui jouent un r\u00f4le important dans la sant\u00e9 m\u00e9tabolique, immunitaire et intestinale.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/li>\n<li><span data-contrast=\"auto\">Une compr\u00e9hension approfondie de cette phase permet de progresser vers des solutions \u00e0 des probl\u00e9matiques plus complexes, telles que<strong><a href=\"https:\/\/www.ainia.com\/fr\/ainia-news\/comment-aborder-de-maniere-plus-efficace-la-complexite-de-linflammation-intestinale-et-du-cancer-colorectal\/\"> l\u2019inflammation intestinale chronique ou le cancer colorectal.<\/a><\/strong><\/span><strong>\u00a0<\/strong><\/li>\n<li><span data-contrast=\"auto\">Le contenu peut rester entre 12 et 24 heures avant d\u2019\u00eatre \u00e9limin\u00e9 par le rectum sous forme de mati\u00e8res f\u00e9cales.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/li>\n<\/ul>\n<h2><strong><img decoding=\"async\" class=\"alignnone size-large wp-image-181261\" src=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/07\/digestor-dinamico-tres-1024x682.jpg\" alt=\"digestor dinamico\" width=\"1024\" height=\"682\" srcset=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/07\/digestor-dinamico-tres-1024x682.jpg 1024w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/07\/digestor-dinamico-tres-300x200.jpg 300w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/07\/digestor-dinamico-tres-768x511.jpg 768w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/07\/digestor-dinamico-tres.jpg 1080w\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><\/strong><\/h2>\n<h2 aria-level=\"2\"><strong>Mod\u00e8les de simulation des \u00e9tapes de la digestion pour valider les ingr\u00e9dients actifs\u00a0<\/strong><\/h2>\n<p><span data-contrast=\"auto\">Pour obtenir des preuves scientifiques sur l\u2019effet r\u00e9el d\u2019un <\/span><b><span data-contrast=\"auto\">ingr\u00e9dient actif<\/span><\/b><span data-contrast=\"auto\"> dans l\u2019organisme, les <a href=\"https:\/\/www.ainia.com\/fr\/essais-en-digesteur-dynamique-in-vitro-bioaccessibilite-et-essais-en-culture-cellulaire-biodisponibilite\/\"><strong>mod\u00e8les de digestion <\/strong><\/a><\/span><strong><i>in vitro<\/i><\/strong><span data-contrast=\"auto\"> se sont impos\u00e9s comme un outil essentiel. Ces essais permettent de simuler, de mani\u00e8re contr\u00f4l\u00e9e, les conditions physiologiques qui se produisent tout au long des <\/span><b><span data-contrast=\"auto\">\u00e9tapes de la digestion<\/span><\/b><span data-contrast=\"auto\"> \u2014 de la phase orale \u00e0 la fermentation colique.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Les mod\u00e8les dynamiques <\/span><i><span data-contrast=\"auto\">in vitro<\/span><\/i><span data-contrast=\"auto\"> reproduisent avec pr\u00e9cision des variables cl\u00e9s telles que le pH, le temps de transit, la pr\u00e9sence d\u2019enzymes digestives et la concentration en sels \u00e0 chaque \u00e9tape du syst\u00e8me digestif.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">En plus de permettre l\u2019\u00e9tude du comportement d\u2019un ingr\u00e9dient dans le tractus gastro-intestinal, ils constituent une m\u00e9thode efficace pour analyser son effet fonctionnel ou b\u00e9n\u00e9fique apr\u00e8s la digestion et l\u2019absorption. Cette approche est \u00e9galement appliqu\u00e9e avec succ\u00e8s dans le domaine de la sant\u00e9 digestive animale, o\u00f9 les simulateurs <\/span><i><span data-contrast=\"auto\">in vitro<\/span><\/i><span data-contrast=\"auto\"> permettent d\u2019\u00e9valuer des <a href=\"https:\/\/www.ainia.com\/fr\/ainia-news\/comment-savoir-si-un-ingredient-ameliore-la-sante-digestive-des-animaux-la-cle-reside-dans-les-preuves-scientifiques-obtenues-par-la-simulation-du-tractus-gastro-intestinal-in-vitro\/\"><strong>ingr\u00e9dients fonctionnels sans recourir \u00e0 des essais sur les animaux.<\/strong><\/a><\/span><strong>\u00a0<\/strong><\/p>\n<p><span data-contrast=\"auto\">Ces essais incluent g\u00e9n\u00e9ralement :<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"23\" data-list-defn-props='{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}' data-aria-posinset=\"1\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Phase orale<\/span><\/b><span data-contrast=\"auto\">, o\u00f9 l\u2019on \u00e9value la lib\u00e9ration initiale de l\u2019ingr\u00e9dient.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"23\" data-list-defn-props='{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}' data-aria-posinset=\"2\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Phase gastrique<\/span><\/b><span data-contrast=\"auto\">, pour \u00e9tudier sa stabilit\u00e9 en conditions acides.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"23\" data-list-defn-props='{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}' data-aria-posinset=\"3\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Phase intestinale<\/span><\/b><span data-contrast=\"auto\">, essentielle pour d\u00e9terminer sa biodisponibilit\u00e9.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"23\" data-list-defn-props='{\"335552541\":1,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}' data-aria-posinset=\"4\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Phase colique<\/span><\/b><span data-contrast=\"auto\">, qui permet d\u2019analyser la fermentation microbienne et la production de m\u00e9tabolites actifs.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/li>\n<\/ul>\n<p><span data-contrast=\"auto\">Apr\u00e8s la digestion, l\u2019absorption intestinale peut \u00eatre simul\u00e9e \u00e0 l\u2019aide de mod\u00e8les cellulaires tels que la lign\u00e9e Caco-2, repr\u00e9sentative de l\u2019\u00e9pith\u00e9lium intestinal humain. Cette technique permet d\u2019estimer la fraction du compos\u00e9 ing\u00e9r\u00e9 susceptible d\u2019atteindre la circulation sanguine (fraction biodisponible), ce qui est fondamental pour les ingr\u00e9dients ayant un effet syst\u00e9mique.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Gr\u00e2ce \u00e0 leur polyvalence, leur reproductibilit\u00e9 et leur co\u00fbt r\u00e9duit par rapport aux \u00e9tudes <\/span><i><span data-contrast=\"auto\">in vivo<\/span><\/i><span data-contrast=\"auto\">, ces mod\u00e8les sont de plus en plus utilis\u00e9s, tant en recherche que pour le d\u00e9veloppement de nouveaux produits nutraceutiques, fonctionnels et v\u00e9t\u00e9rinaires.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":1,\"335551620\":1,\"335559738\":240,\"335559739\":240}'>[\/vc_column_text]\u00a0\u00a0<\/span><\/p>\n<\/div><\/body><\/html>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text css=\u201d\u201d]Comprendre, \u00e9valuer et d\u00e9montrer le m\u00e9canisme d\u2019action des ingr\u00e9dients fonctionnels est essentiel pour les entreprises du secteur. La soci\u00e9t\u00e9 se tourne de plus en plus vers ces compos\u00e9s pour compl\u00e9ter son alimentation, mais il ne suffit pas de les incorporer dans une formulation. Leur inclusion doit \u00eatre justifi\u00e9e selon des crit\u00e8res scientifiques rigoureux : [&hellip;]<\/p>\n","protected":false},"author":236,"featured_media":173428,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1976],"tags":[],"class_list":["post-184094","post","type-post","status-publish","format-standard","hentry","category-innovation-technologique"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Validation des compos\u00e9s bioactifs: les 5 \u00e9tapes de la digestion<\/title>\n<meta name=\"description\" content=\"Les \u00e9tapes de la digestion : orale, gastrique, intestinale et colique. 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