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La recherche sur le d\u00e9veloppement de th\u00e9rapies innovantes pour traiter l\u2019inflammation intestinale chronique et pr\u00e9venir le cancer colorectal est essentielle pour am\u00e9liorer la qualit\u00e9 de vie des patients et r\u00e9duire l\u2019impact de cette maladie sur la soci\u00e9t\u00e9. La combinaison des avanc\u00e9es en biochimie, biologie mol\u00e9culaire et technologie th\u00e9rapeutique offre des opportunit\u00e9s prometteuses dans ce domaine de la m\u00e9decine. \u00c0 cet \u00e9gard, chez AINIA, nous menons des recherches sur la d\u00e9couverte et le d\u00e9veloppement de th\u00e9rapies innovantes utilisant des biomol\u00e9cules naturelles, permettant de concevoir des strat\u00e9gies novatrices pour pr\u00e9venir et traiter les processus inflammatoires associ\u00e9s au cancer colorectal. Voici ce que nous savons.<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

Strat\u00e9gies de recherche pour traiter l\u2019inflammation intestinale et pr\u00e9venir le cancer colorectal<\/h2>\n
Le lien entre l\u2019inflammation chronique et le cancer colorectal<\/strong> est un domaine d\u2019int\u00e9r\u00eat dans la recherche biom\u00e9dicale et pharmaceutique, et des efforts sont faits pour mieux comprendre les m\u00e9canismes sous-jacents et d\u00e9velopper des traitements plus efficaces avec moins d\u2019effets secondaires.<\/p>\n
Parmi les strat\u00e9gies de recherche, les suivantes se distinguent :<\/p>\n
\n
Th\u00e9rapies avec des biomol\u00e9cules naturelles<\/strong> : Compte tenu du potentiel bioactif pr\u00e9sent dans la nature, les biomol\u00e9cules d\u2019origine naturelle, comme celles trouv\u00e9es dans les plantes et les micro-organismes, repr\u00e9sentent une source prometteuse de compos\u00e9s th\u00e9rapeutiques. La recherche sur ces mol\u00e9cules peut conduire au d\u00e9veloppement de traitements plus s\u00fbrs et plus efficaces pour l\u2019inflammation intestinale et la pr\u00e9vention du cancer colorectal.<\/li>\n
Identification de cibles th\u00e9rapeutiques sp\u00e9cifiques<\/strong> : En plus de nouvelles th\u00e9rapies, une autre strat\u00e9gie pour traiter et\/ou pr\u00e9venir la maladie est l\u2019identification de cibles th\u00e9rapeutiques sp\u00e9cifiques. L\u2019\u00e9lucidation des m\u00e9canismes mol\u00e9culaires et cellulaires impliqu\u00e9s dans l\u2019inflammation intestinale chronique et sa relation avec le cancer colorectal est essentielle. Identifier des cibles th\u00e9rapeutiques sp\u00e9cifiques<\/strong> permet de d\u00e9velopper des traitements cibl\u00e9s qui peuvent \u00eatre plus efficaces et s\u00e9lectifs. Des th\u00e9rapies plus sp\u00e9cifiques peuvent aider \u00e0 r\u00e9duire les effets ind\u00e9sirables, ce qui am\u00e9liore la qualit\u00e9 de vie des patients et augmente l\u2019adh\u00e9sion au traitement.<\/li>\n
Strat\u00e9gies de pr\u00e9vention : <\/strong>Outre le traitement, il est important de se concentrer sur les strat\u00e9gies de pr\u00e9vention. Cela inclut l\u2019identification pr\u00e9coce des populations \u00e0 risque, la promotion d\u2019habitudes de vie saines et la sensibilisation \u00e0 l\u2019importance de la d\u00e9tection pr\u00e9coce du cancer colorectal.<\/li>\n<\/ul>\n
Collaboration interdisciplinaire : la cl\u00e9 pour aborder efficacement la complexit\u00e9 de l\u2019inflammation intestinale et du cancer colorectal<\/h2>\n
La recherche dans ce domaine n\u00e9cessite souvent la collaboration interdisciplinaire<\/strong> d\u2019experts en biologie mol\u00e9culaire, biochimie, pharmacologie, immunologie et oncologie, entre autres disciplines. Cette collaboration permet une approche plus efficace face aux complexit\u00e9s de l\u2019inflammation intestinale et du cancer colorectal.<\/p>\n
La recherche sur le d\u00e9veloppement de th\u00e9rapies innovantes pour traiter l\u2019inflammation intestinale chronique et pr\u00e9venir le cancer colorectal est cruciale pour am\u00e9liorer la qualit\u00e9 de vie<\/strong> des patients et r\u00e9duire le fardeau de cette maladie sur la soci\u00e9t\u00e9. La combinaison des avanc\u00e9es en biochimie, biologie mol\u00e9culaire et technologie th\u00e9rapeutique offre des opportunit\u00e9s prometteuses dans ce domaine de la m\u00e9decine.<\/p>\n
Recherche et d\u00e9veloppement de th\u00e9rapies pour pr\u00e9venir et traiter les processus inflammatoires associ\u00e9s au cancer colorectal<\/h2>\n
Sur la base de tout ce qui a \u00e9t\u00e9 mentionn\u00e9 ci-dessus, chez AINIA, nous d\u00e9veloppons le projet PHARMANOVA,<\/strong> dans lequel nous rechercherons le d\u00e9veloppement d\u2019outils et de solutions technologiques pour les secteurs biotechnologique, biom\u00e9dical et pharmaceutique, afin de d\u00e9couvrir et d\u00e9velopper des th\u00e9rapies innovantes et cibl\u00e9es bas\u00e9es sur des biomol\u00e9cules<\/strong> naturelles d\u2019origine v\u00e9g\u00e9tale et microbienne. Cela nous permettra de concevoir des strat\u00e9gies innovantes pour pr\u00e9venir et traiter les processus inflammatoires associ\u00e9s aux maladies de la muqueuse colique et au cancer colorectal.<\/p>\n
En fonction des besoins pour avancer dans la d\u00e9couverte et le d\u00e9veloppement de th\u00e9rapies innovantes bas\u00e9es sur des biomol\u00e9cules, la recherche men\u00e9e dans le cadre de PHARMANOVA nous permettra d\u2019obtenir les r\u00e9sultats suivants :<\/p>\n
\n
Outils agiles et rapides<\/strong> pour d\u00e9couvrir de nouvelles mol\u00e9cules \u00e0 des fins th\u00e9rapeutiques gr\u00e2ce au d\u00e9veloppement de syst\u00e8mes ou plateformes de criblage rapide \u00e0 \u00e9chelle miniaturis\u00e9e. Un syst\u00e8me de criblage<\/strong> bas\u00e9 sur un syst\u00e8me cellulaire repr\u00e9sentatif de la pathologie \u00e9tudi\u00e9e et une plateforme microbienne pour rechercher des compos\u00e9s potentiellement th\u00e9rapeutiques.<\/li>\n
Outils pr\u00e9cis pour caract\u00e9riser l\u2019effet biologique<\/strong> en utilisant des technologies omiques.<\/li>\n
Technologies bas\u00e9es sur le CO2 supercritique pour le fractionnement<\/strong> des sources potentielles (ou matrices) de mol\u00e9cules th\u00e9rapeutiques afin d\u2019obtenir des concentr\u00e9s de biomol\u00e9cules.<\/li>\n
Syst\u00e8mes de lib\u00e9ration contr\u00f4l\u00e9e<\/strong> pour garantir que la mol\u00e9cule th\u00e9rapeutique atteigne la cible biologique et exerce son action.<\/li>\n
Mod\u00e8les cellulaires avanc\u00e9s in vitro<\/strong><\/a> bas\u00e9s sur des technologies de bioimpression 3D et d\u2019organes sur puce pour valider l\u2019efficacit\u00e9 des biomol\u00e9cules et \u00e9tudier leur m\u00e9canisme d\u2019action.<\/li>\n<\/ul>\n
Recherche de solutions technologiques pour le d\u00e9veloppement de produits th\u00e9rapeutiques pour les processus inflammatoires associ\u00e9s au cancer colorectal<\/h2>\n
Gr\u00e2ce aux r\u00e9sultats du projet PHARMANOVA<\/strong>, AINIA vise \u00e0 fournir des solutions technologiques aux entreprises du secteur de la biotechnologie de la sant\u00e9 de la Communaut\u00e9 valencienne pour la d\u00e9couverte et le d\u00e9veloppement de produits th\u00e9rapeutiques qui pr\u00e9viennent ou traitent les processus inflammatoires associ\u00e9s aux maladies de la muqueuse colique et au cancer colorectal.<\/p>\n
Nouveaux M\u00e9thodes pour la Validation des M\u00e9dicaments<\/strong><\/h2>\n
Aux \u00c9tats-Unis, une nouvelle loi sign\u00e9e \u00e0 la fin de d\u00e9cembre 2022 permet \u00e0 la Food and Drug Administration (FDA) d\u2019approuver de nouveaux m\u00e9dicaments sans avoir recours aux tests sur animaux.<\/p>\n
Gr\u00e2ce \u00e0 cette loi, d\u2019autres m\u00e9thodes sont d\u00e9sormais utilis\u00e9es pour valider les m\u00e9dicaments, telles que les mini-organes humains (organo\u00efdes), les organes sur puce et les m\u00e9thodes informatiques, au lieu des m\u00e9thodes traditionnelles de tests sur animaux. Ces m\u00e9thodes se sont av\u00e9r\u00e9es plus pr\u00e9cises et fiables que les tests sur animaux.<\/p>\n
Ces types d\u2019\u00e9tudes in vitro<\/a> s\u2019alignent sur les recherches d\u00e9velopp\u00e9es par la ligne d\u2019\u00e9tudes pr\u00e9cliniques avec des mod\u00e8les in vitro, qui disposent de technologies et de savoir-faire bas\u00e9s sur des syst\u00e8mes exp\u00e9rimentaux reproduisant le syst\u00e8me gastro-intestinal et la microbiote colique<\/a>, ainsi que sur la technologie de culture cellulaire, l\u2019ing\u00e9nierie tissulaire et la microfluidique.[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div><\/body><\/html>","protected":false},"excerpt":{"rendered":"
[vc_row][vc_column][vc_column_text css=\u201d\u201d] La recherche sur le d\u00e9veloppement de th\u00e9rapies innovantes pour traiter l\u2019inflammation intestinale chronique et pr\u00e9venir le cancer colorectal est essentielle pour am\u00e9liorer la qualit\u00e9 de vie des patients et r\u00e9duire l\u2019impact de cette maladie sur la soci\u00e9t\u00e9. La combinaison des avanc\u00e9es en biochimie, biologie mol\u00e9culaire et technologie th\u00e9rapeutique offre des opportunit\u00e9s prometteuses dans […]<\/p>\n","protected":false},"author":236,"featured_media":174346,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1976],"tags":[],"class_list":["post-174345","post","type-post","status-publish","format-standard","hentry","category-innovation-technologique"],"acf":[],"yoast_head":"\nTh\u00e9rapies pour l'inflammation intestinale et le cancer colorectal<\/title>\n<meta name=\"description\" content=\"Technologies innovantes en biochimie, biologie mol\u00e9culaire et technologie th\u00e9rapeutique pour aborder les processus inflammatoires associ\u00e9s au cancer colorectal.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link 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Adem\u00e1s, imparto formaci\u00f3n especializada en congresos y jornadas sectoriales, contribuyendo a la divulgaci\u00f3n cient\u00edfica y al avance de la investigaci\u00f3n aplicada.","sameAs":["https:\/\/www.ainia.com\/contactar-lidia-tomas\/","=https:\/\/www.linkedin.com\/public-profile\/settings?lipi=urnlipaged_flagship3_profile_self_edit_contact-infoSUVPYk6QOSvsEj2ZXWSXQ"],"url":"https:\/\/www.ainia.com\/fr\/ainia-news\/author\/lidia-tomas-cobos\/"}]}},"_links":{"self":[{"href":"https:\/\/www.ainia.com\/fr\/wp-json\/wp\/v2\/posts\/174345","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ainia.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ainia.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ainia.com\/fr\/wp-json\/wp\/v2\/users\/236"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ainia.com\/fr\/wp-json\/wp\/v2\/comments?post=174345"}],"version-history":[{"count":5,"href":"https:\/\/www.ainia.com\/fr\/wp-json\/wp\/v2\/posts\/174345\/revisions"}],"predecessor-version":[{"id":179735,"href":"https:\/\/www.ainia.com\/fr\/wp-json\/wp\/v2\/posts\/174345\/revisions\/179735"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ainia.com\/fr\/wp-json\/wp\/v2\/media\/174346"}],"wp:attachment":[{"href":"https:\/\/www.ainia.com\/fr\/wp-json\/wp\/v2\/media?parent=174345"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ainia.com\/fr\/wp-json\/wp\/v2\/categories?post=174345"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ainia.com\/fr\/wp-json\/wp\/v2\/tags?post=174345"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}