Lactobacillus reuteri bacteria - AINIA<\/title>\n<meta name=\"description\" content=\"Discover Lactobacillus reuteri properties, benefits, key strains and emerging applications, plus the design and evaluation factors needed for viable probiotic products.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ainia.com\/en\/ainia-news\/lactobacillus-reuteri-bacteria-benefits-types-and-probiotic-applications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lactobacillus reuteri bacteria - AINIA\" \/>\n<meta property=\"og:description\" content=\"Discover Lactobacillus reuteri properties, benefits, key strains and emerging applications, plus the design and evaluation factors needed for viable probiotic products.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ainia.com\/en\/ainia-news\/lactobacillus-reuteri-bacteria-benefits-types-and-probiotic-applications\/\" \/>\n<meta property=\"og:site_name\" content=\"AINIA\" \/>\n<meta property=\"article:published_time\" content=\"2026-03-12T12:42:09+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-02T12:20:58+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2026\/03\/ChatGPT-Image-13-oct-2025-12_47_34-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"800\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Sonia Porta\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sonia Porta\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.ainia.com\\\/en\\\/ainia-news\\\/lactobacillus-reuteri-bacteria-benefits-types-and-probiotic-applications\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ainia.com\\\/en\\\/ainia-news\\\/lactobacillus-reuteri-bacteria-benefits-types-and-probiotic-applications\\\/\"},\"author\":{\"name\":\"Sonia Porta\",\"@id\":\"https:\\\/\\\/www.ainia.com\\\/en\\\/#\\\/schema\\\/person\\\/40e1dbe0414a9868d15dde2efcd92c5e\"},\"headline\":\"Lactobacillus reuteri bacteria: benefits, types and probiotic applications\",\"datePublished\":\"2026-03-12T12:42:09+00:00\",\"dateModified\":\"2026-04-02T12:20:58+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.ainia.com\\\/en\\\/ainia-news\\\/lactobacillus-reuteri-bacteria-benefits-types-and-probiotic-applications\\\/\"},\"wordCount\":904,\"publisher\":{\"@id\":\"https:\\\/\\\/www.ainia.com\\\/en\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ainia.com\\\/en\\\/ainia-news\\\/lactobacillus-reuteri-bacteria-benefits-types-and-probiotic-applications\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.ainia.com\\\/wp-content\\\/uploads\\\/2026\\\/03\\\/ChatGPT-Image-13-oct-2025-12_47_34-1.jpg\",\"articleSection\":[\"Technological innovation\"],\"inLanguage\":\"en\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ainia.com\\\/en\\\/ainia-news\\\/lactobacillus-reuteri-bacteria-benefits-types-and-probiotic-applications\\\/\",\"url\":\"https:\\\/\\\/www.ainia.com\\\/en\\\/ainia-news\\\/lactobacillus-reuteri-bacteria-benefits-types-and-probiotic-applications\\\/\",\"name\":\"Lactobacillus reuteri bacteria - 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In this article we explain everything about the probiotic<\/strong> Lactobacillus reuteri<\/strong><\/em>, known for its ability to modulate the microbiota, produce antimicrobial compounds and support the intestinal barrier. We will also review the properties, types\/strains<\/strong> most commonly used, benefits<\/strong> and the key aspects of design and evaluation<\/strong> required to transform them into viable products.<\/p>\n<\/nav>\n

\n
\n
Lactobacillus reuteri<\/em>: properties, benefits and applications<\/a><\/strong><\/li>\n
Properties of Lactobacillus reuteri<\/em><\/a><\/strong><\/li>\n
Benefits of the probiotic Lactobacillus reuteri<\/em><\/a><\/strong><\/li>\n
Emerging industrial applications<\/a><\/strong><\/li>\n
Probiotic Lactobacillus reuteri<\/em>: types<\/a><\/strong><\/li>\n
Probiotic Lactobacillus reuteri<\/em>: design and evaluation<\/a><\/strong><\/li>\n<\/ul>\n<\/section>\n\n
Properties of Lactobacillus reuteri<\/em>: what is it used for?<\/strong><\/h2>\nProbiotics<\/strong><\/a> are widely known for their benefits in digestive, immune and even oral health. The probiotic Lactobacillus reuteri<\/em><\/strong> is a microorganism<\/strong> that naturally colonises the gastrointestinal tract of humans and other mammals. It stands out for three key functional properties:<\/p>\n
\n
Adhesion capacity and microbiota modulation:<\/strong>
\nIt adheres to the intestinal mucosa, helping to balance the microbiota<\/strong> and promote a more stable microbial community.<\/li>\n
Production of bioactive compounds:<\/strong>
\nSome strains, those capable of metabolising glycerol, produce reuterin<\/strong> and other antimicrobial substances that inhibit<\/strong> pathogens<\/strong> (for example, enterobacteria or Candida), contributing to colonisation resistance.<\/li>\n
In addition, reuterin<\/strong> acts against pathogenic microorganisms such as: E. coli, Salmonella, Clostridioides difficile or Candida albicans. Its activity does not depend on pH<\/strong> and is effective at low concentrations. This makes it a clear differentiating factor compared with other probiotics.<\/li>\n
Immunomodulatory effect: <\/strong>It can modulate the inflammatory response<\/strong> and support the intestinal<\/strong> barrier<\/strong>, with potential impact on functional digestive discomfort (e.g., episodes of abdominal pain, bloating or altered transit).<\/li>\n<\/ul>\n<\/section>\n
$\"Digestive$ \n
Benefits of the probiotic Lactobacillus reuteri<\/em><\/strong><\/h3>\n
Potential benefits depend on the strain<\/strong>, the effective dose<\/strong>, the quality of the formulation<\/strong> and the target population<\/strong>.<\/p>\n
The most notable benefits of the probiotic Lactobacillus reuteri<\/em> are:<\/p>\n
\n
Digestive health:<\/strong> support in acute diarrhoea, prevention of antibiotic-associated diarrhoea, functional gastrointestinal discomfort and transit regulation.<\/li>\n
Oral health:<\/strong> reduction of plaque and halitosis, and gum support.<\/li>\n
Infant health:<\/strong> digestive support in infants.<\/li>\n
Metabolic\/inflammatory health:<\/strong> signals of cytokine modulation and interaction with the gut\u2013immune system axis.<\/li>\n<\/ul>\n<\/section>\n
\n
Emerging industrial applications<\/strong><\/h3>\n
\n
Beneficial biofilms in aquaculture:<\/strong> some strains are used to compete with Vibrio.<\/li>\n
Use in animal nutrition:<\/strong> improves intestinal health in piglets and poultry.<\/li>\n
Applications in oral health (PTA 5289):<\/strong><\/li>\n<\/ul>\n
\n
reduction of Streptococcus mutans<\/em><\/li>\n
modulation of the oral biofilm<\/li>\n
use in dental prostheses<\/li>\n<\/ol>\n<\/section>\n
\n
Probiotic Lactobacillus reuteri<\/em>: types<\/h2>\n
In probiotics, the type of strain defines the use, the evidence and the optimal formulation approach.<\/p>\n
These are the criteria you should consider when selecting a strain:<\/strong><\/p>\n
\n
Clearly defined indication and target population<\/li>\n
Strain with a traceable scientific dossier and deposit in a recognised collection<\/li>\n
Effective dose expressed in CFU per day and appropriate delivery format<\/li>\n
Real stability over shelf life and compatibility with the rest of the ingredients<\/li>\n
Regulatory compliance and a clear labelling strategy<\/li>\n<\/ul>\n
DSM 17938 strain<\/strong><\/h3>\n
This is the most widely used reference strain for digestive health, with a particular focus on the infant population. Evidence supports its gastrointestinal benefits, reduction of diarrhoeal episodes and balance of intestinal transit.<\/p>\n
It is usually used in liquid and powder formulations, with matrices designed to protect viability<\/a> during storage and use.<\/p>\n
ATCC PTA 6475 strain<\/strong><\/h3>\n
Selected for its immunomodulatory profile and support for intestinal barrier integrity. It is aimed at adults and developments seeking to modulate low-grade inflammation.<\/p>\n
It requires careful work on stability and excipient selection to preserve functionality and viable counts.<\/p>\n
ATCC PTA 5289 strain<\/strong><\/h3>\n
Commonly used in oral health solutions. It has been used in combinations aimed at plaque reduction, bad breath control and gingival care.<\/p>\n
The delivery format can come in different forms:<\/p>\n
\n
Buccal tablets<\/li>\n
Gummies<\/li>\n
Local-release formats<\/li>\n<\/ul>\n
These formats maximise contact with the biofilm and enhance the effect.<\/p>\n
ATCC 55730 strain<\/strong><\/h3>\n
Historically relevant for its clinical use, although its replacement by DSM 17938 responded to safety criteria related to antibiotic resistance determinations.<\/p>\n<\/section>\n
\n
Probiotic Lactobacillus reuteri<\/em>: design and evaluation<\/h2>\n
To turn a probiotic into a competitive, reliable, safe and effective product<\/strong>, development must integrate strain selection, formulation, preclinical and clinical validation, and a coherent regulatory and shelf-life strategy.<\/p>\n
At AINIA we address the full cycle with a focus on the real performance of the probiotic and its viability until the end of shelf life<\/strong>.<\/p>\n
\n
Definition of indication and strain selection:<\/strong> We define the health objective and from there establish the positioning: dose, delivery format and future clinical endpoints.<\/li>\n
Formulation and stability:<\/strong> We optimise the matrix and excipients to protect the viability of the microorganism<\/strong> against oxygen, humidity and temperature. We use proven stabilisation technologies such as lyophilisation and spray drying, and validate their impact on viable count and functionality.<\/li>\n
Preclinical validation with advanced models:<\/strong> We verify gastric and intestinal survival and functionality using an in vitro Dynamic Digester, colonic fermentation models and cellular models<\/a> that allow the study of gastrointestinal resistance, absorption and microbiota modulation.<\/li>\n
Clinical translation and regulatory strategy:<\/strong> We design clinical studies aligned with the indication and the target population, with variables such as days of diarrhoea, digestive comfort or inflammation markers, and collaborate with healthcare centres to obtain robust evidence. In parallel, we define the product\u2019s regulatory framework, its labelling and quality requirements.<\/li>\n
Scale-up and shelf-life control:<\/strong> We take the development to pilot and industrial scale, selecting barrier packaging and logistics conditions that preserve viability. Throughout the process, we perform accelerated and real-condition stability studies, and revalidate performance in in vitro digestion when significant formulation changes occur $\"Genocare\"$ Funded<\/span>\u00a0<\/span>by<\/span>\u00a0<\/span>the<\/span>\u00a0<\/span>aid<\/span>\u00a0<\/span>program<\/span>\u00a0<\/span>for<\/span>\u00a0<\/span>hiring<\/span>\u00a0<\/span>young<\/span>\u00a0<\/span>professionals<\/span>\u00a0<\/span>specialized<\/span>\u00a0in\u00a0<\/span>internationalization<\/span><\/strong><\/em><\/li>\n<\/ul>\n
$\"\"$ <\/p>\n<\/section>\n<\/article>\n<\/body><\/html>","protected":false},"excerpt":{"rendered":"
In this article we explain everything about the probiotic Lactobacillus reuteri, known for its ability to modulate the microbiota, produce antimicrobial compounds and support the intestinal barrier. We will also review the properties, types\/strains most commonly used, benefits and the key aspects of design and evaluation required to transform them into viable products. Lactobacillus reuteri: […]<\/p>\n","protected":false},"author":286,"featured_media":189103,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1971],"tags":[],"class_list":["post-189459","post","type-post","status-publish","format-standard","hentry","category-technological-innovation"],"acf":[],"yoast_head":"\nLactobacillus reuteri bacteria - AINIA<\/title>\n<meta name=\"description\" content=\"Discover Lactobacillus reuteri properties, benefits, key strains and emerging applications, plus the design and evaluation factors needed for viable probiotic products.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ainia.com\/en\/ainia-news\/lactobacillus-reuteri-bacteria-benefits-types-and-probiotic-applications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lactobacillus reuteri bacteria - 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ATCC PTA 5289 strain<\/strong><\/h3>\nCommonly used in oral health solutions. It has been used in combinations aimed at plaque reduction, bad breath control and gingival care.<\/p>\nThe delivery format can come in different forms:<\/p>\n\nBuccal tablets<\/li>\nGummies<\/li>\n