{"id":188682,"date":"2026-03-17T14:39:36","date_gmt":"2026-03-17T13:39:36","guid":{"rendered":"https:\/\/www.ainia.com\/?p=188682"},"modified":"2026-03-18T13:06:16","modified_gmt":"2026-03-18T12:06:16","slug":"biotechnological-advances-to-transform-plant-residues-into-compounds-against-colon-inflammation","status":"publish","type":"post","link":"https:\/\/www.ainia.com\/en\/ainia-news\/biotechnological-advances-to-transform-plant-residues-into-compounds-against-colon-inflammation\/","title":{"rendered":"Biotechnological advances to transform plant residues into compounds against colon inflammation"},"content":{"rendered":"

Within the framework of the PHARMANOVA II project, AINIA has developed new biotechnological solutions based on plant by-products<\/a><\/strong> to treat inflammatory diseases of the colon, such as ulcerative colitis or Crohn\u2019s disease. To achieve this, four key technologies have been used: in vitro<\/em> technology based on 3D cellular models, separation technologies, chemical characterisation technologies and controlled release technologies.<\/p>\n

One of the main advances has been the improvement of a cell platform<\/strong> that rapidly and reliably identifies natural molecules with therapeutic potential. This has made it possible to verify the anti-inflammatory effect of plant extracts such as pomegranate and pistachio.<\/p>\n

\"AINIA<\/strong><\/h2>\n

3D models and gut-on-chip that mimic the response of the human colon<\/strong><\/h2>\n

Within the framework of this project, the AINIA team has developed advanced cellular models<\/strong> from human colorectal carcinoma cells to study their mechanism of action. Among the techniques developed, 3D culture techniques<\/strong> stand out for the generation of intestinal spheroids<\/strong>, three-dimensional cellular structures that mimic the organisation and behaviour of human tissue. Based on these, 3D inflamed colon models<\/strong> have been created, allowing a more representative evaluation of the response of intestinal cells to natural compounds with therapeutic potential. In particular, with this technology it has been possible to observe the anti-inflammatory action of a postbiotic \u2014a beneficial compound produced during fermentation\u2014 and pomegranate extract.<\/p>\n

In addition, an innovative technology known as gut-on-chip<\/em><\/strong> has been used, a small device that simulates the conditions of the human intestine. This tool allows real-time monitoring of how inflammatory processes evolve and how the studied compounds act on them.<\/p>\n

Cleaner technologies to obtain natural ingredients of interest<\/strong><\/h2>\n

Another line of work has focused on using supercritical CO\u2082, a more sustainable and environmentally friendly extraction technology. Thanks to this method, more stable pomegranate and pistachio fractions have been obtained with a higher concentration of compounds that may contribute to improving inflammatory processes.<\/a><\/strong><\/p>\n

To analyse these extracts accurately, the team has also developed a technique that makes it possible to reliably measure the presence of tocotrienols, a type of vitamin E with antioxidant properties and potential benefits against inflammation.<\/p>\n

Towards more effective and natural treatments<\/strong><\/h2>\n

The project has also made it possible to design a double encapsulation system that protects natural compounds during digestion, ensuring that they reach the colon, where they must exert their action.<\/p>\n

PHARMANOVA II is a project supported by IVACE<\/a>,<\/strong> through the FEDER Comunitat Valenciana 2021-2027 Programme funded by the European Union, and developed in collaboration with the companies Nova Terra Foods and Monteloeder.<\/p>\n

\n<\/p>

\"Logo<\/p>\n<\/body><\/html>","protected":false},"excerpt":{"rendered":"

Within the framework of the PHARMANOVA II project, AINIA has developed new biotechnological solutions based on plant by-products to treat inflammatory diseases of the colon, such as ulcerative colitis or Crohn\u2019s disease. To achieve this, four key technologies have been used: in vitro technology based on 3D cellular models, separation technologies, chemical characterisation technologies and […]<\/p>\n","protected":false},"author":198,"featured_media":185210,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[974],"tags":[],"class_list":["post-188682","post","type-post","status-publish","format-standard","hentry","category-press-releases"],"acf":[],"yoast_head":"\nAINIA develops technologies against colon inflammation - AINIA<\/title>\n<meta name=\"description\" content=\"AINIA achieves biotechnological advances to transform plant residues into compounds against colon inflammation\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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