{"id":188338,"date":"2026-03-09T14:39:16","date_gmt":"2026-03-09T13:39:16","guid":{"rendered":"https:\/\/www.ainia.com\/?p=188338"},"modified":"2026-03-09T14:45:24","modified_gmt":"2026-03-09T13:45:24","slug":"nutrigenomics-what-it-is-and-how-snp-nucleotides-define-the-nutrigenetic-profile-2","status":"publish","type":"post","link":"https:\/\/www.ainia.com\/en\/ainia-news\/nutrigenomics-what-it-is-and-how-snp-nucleotides-define-the-nutrigenetic-profile-2\/","title":{"rendered":"Nutrigenomics: What It Is and How SNP Nucleotides Define the Nutrigenetic Profile"},"content":{"rendered":"<html><body><p>How can genetic data be integrated into dietetic practice? In this article, we explain <strong>what nutrigenomics is<\/strong> and show how <strong>nucleotides<\/strong> make it possible to define a solid nutrigenetic profile. Based on that foundation, we outline an approach to translating genetic information into personalised recommendations aligned with the principles of <a href=\"https:\/\/www.ainia.com\/linea-idi\/nutricion-precision\/\"><strong>precision nutrition.<\/strong><\/a><\/p>\n<article><!-- INDEX -->\n<nav aria-label=\"Index\"><strong>Index<\/strong>\n<ul>\n<li><a href=\"#nutrigenomica-que-es\">Nutrigenomics: what it is<\/a><\/li>\n<li><a href=\"#diferencias-nutrigenomica-nutrigenetica\">Differences between nutrigenomics and nutrigenetics<\/a><\/li>\n<li><a href=\"#test-de-nutrigenomica\">Nutrigenomics test<\/a><\/li>\n<li><a href=\"#snp-nucleotide-perfil-nutrigenetico\">SNP nucleotide: How to establish a nutrigenetic profile<\/a><\/li>\n<li><a href=\"#importancia-nutricion-precision\">Importance in precision nutrition<\/a><\/li>\n<\/ul>\n<\/nav>\n<p><!-- CONTENT --><\/p>\n<section id=\"nutrigenomica-que-es\">\n<h2>Nutrigenomics: what it is<\/h2>\n<p><strong>Nutrigenomics<\/strong> studies how nutrients and bioactive compounds modulate <strong>gene expression<\/strong> and metabolic pathways. Its aim is to translate this diet-gene interaction into <strong>personalised and measurable dietary recommendations<\/strong>.<\/p>\n<\/section>\n<section id=\"diferencias-nutrigenomica-nutrigenetica\">\n<h3>Differences between nutrigenomics and nutrigenetics<\/h3>\n<ul>\n<li><strong>Nutrigenomics:<\/strong> how diet influences gene expression and biological pathways.<\/li>\n<li><strong>Nutrigenetics:<\/strong> how <strong>genetic variants<\/strong> (e.g., <strong>SNP nucleotide<\/strong>) condition the individual response to nutrients.<\/li>\n<\/ul>\n<p>Both disciplines are complementary: nutrigenetics identifies <strong>susceptibility<\/strong> (which variants a person has), and nutrigenomics helps <strong>modulate<\/strong> the response through dietary and lifestyle changes.<\/p>\n<p><strong>Both are complementary<\/strong>: nutrigenetics profiles susceptibility, and nutrigenomics proposes dietary (and lifestyle) modulations to optimise the response. Recent studies insist on considering polygenicity, effect size and gene-diet-environment interactions.<\/p>\n<\/section>\n<section id=\"test-de-nutrigenomica\">\n<h3>Nutrigenomics test<\/h3>\n<p>A rigorous approach usually includes:<\/p>\n<ol>\n<li><strong>SNP nucleotide panel<\/strong> supported by scientific evidence (folate\/B12 methylation, vitamin D metabolism, lipids, caffeine\/lactose, inflammation, antioxidants, detoxification).<\/li>\n<li><strong>Phenotypic matrix<\/strong>: analytical parameters, habits and objective (weight, performance, cardiometabolic risk).<\/li>\n<li><strong>Evidence-based interpretation<\/strong>: effect size, quality\/replication of studies, possible <strong>interaction with microbiota and lifestyle<\/strong>, and <strong>degree of recommendation<\/strong>. Reviews highlight that, despite the volume of associations, <strong>clinical translation<\/strong> requires caution, independent validation and monitoring of clinical <strong>endpoints<\/strong>.<\/li>\n<\/ol>\n<table>\n<thead>\n<tr>\n<th>Component<\/th>\n<th>What it includes<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>SNP nucleotide panel<\/td>\n<td>folate\/B12 methylation, vitamin D metabolism, lipids, caffeine\/lactose, inflammation, antioxidants, detoxification<\/td>\n<\/tr>\n<tr>\n<td>Phenotypic matrix<\/td>\n<td>analytical parameters, habits and objective (weight, performance, cardiometabolic risk)<\/td>\n<\/tr>\n<tr>\n<td>Evidence-based interpretation<\/td>\n<td>effect size, quality\/replication of studies, possible interaction with microbiota and lifestyle, and degree of recommendation; caution, independent validation and monitoring of clinical endpoints<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n<section id=\"snp-nucleotide-perfil-nutrigenetico\">\n<h2>SNP nucleotide: How to establish a nutrigenetic profile<\/h2>\n<ol>\n<li><strong>Panel selection<\/strong>: prioritise SNPs with <strong>clinical utility<\/strong> and replicated evidence in the target of interest (e.g., lipids, blood pressure, vitamin metabolism).<\/li>\n<li><strong>Sampling and genotyping<\/strong>: saliva\/blood, quality control and coverage; document technical limitations.<\/li>\n<li><strong>Multi-source integration<\/strong>: combine genotype with <strong>biomarkers<\/strong> (e.g., 25(OH)D, lipid profile), dietary records and lifestyle factors; where appropriate, consider <strong>microbiota\/metabolomics<\/strong>.<\/li>\n<li><strong>Practical translation<\/strong>: adjust macros (quality of fats and carbohydrates), <strong>micronutrients<\/strong> (active forms and doses), bioactives (e.g., polyphenols, caffeine according to metabolism) and <strong>behaviours<\/strong> (sleep, activity) that modulate pathways affected by SNPs.<\/li>\n<li><strong>Follow-up and reassessment<\/strong>: define indicators (biomarkers and clinical outcomes) and review the plan in the event of changes in objective or new evidence.<\/li>\n<\/ol>\n<\/section>\n<section id=\"importancia-nutricion-precision\">\n<h2>Importance in precision nutrition<\/h2>\n<p><strong>Precision nutrition<\/strong> seeks to define <strong>personalised dietary strategies<\/strong> to correct metabolic imbalances <strong>and improve quality of life<\/strong>, integrating knowledge of the <strong>intestinal microbiome<\/strong>, the functioning of the <strong>microbiota<\/strong> and the <strong>genetic information<\/strong> of each person. This approach makes it possible to understand with greater granularity how diet impacts the body and to design guidelines tailored to the individual, rather than average recommendations.<\/p>\n<p>The integration of <strong>nutrigenomics and SNPs<\/strong> makes it possible to move from general recommendations to <a href=\"https:\/\/www.ainia.com\/linea-idi\/nutricion-precision\/\"><strong>targeted and measurable interventions<\/strong><\/a>. These are some of the benefits:<\/p>\n<ul>\n<li><strong>Greater clinical response<\/strong>: prioritisation of targets (methylation, inflammation, lipids) with fine-tuned adjustments.<\/li>\n<li><strong>Personalised prevention<\/strong>: early detection of susceptibilities and protective dietary modifications.<\/li>\n<li><strong>Clear risk communication<\/strong>: reports with understandable language, limits and realistic expectations<\/li>\n<\/ul>\n<p>In practice, precision nutrition integrates <strong>multiple dimensions<\/strong> <strong>of the individual<\/strong> (lifestyle, genetics, microbiota, metabolic response) to select targets and measure outcomes objectively, which strengthens <strong>clinical translation<\/strong> and adherence to the guideline.<\/p>\n<p><img decoding=\"async\" class=\"alignnone wp-image-188344 size-large\" src=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2026\/02\/nutrigenomica-2-1-1-1024x683.jpg\" alt=\"scientists in the laboratory (nutrigenomics)\" width=\"1024\" height=\"683\" srcset=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2026\/02\/nutrigenomica-2-1-1-1024x683.jpg 1024w, https:\/\/www.ainia.com\/wp-content\/uploads\/2026\/02\/nutrigenomica-2-1-1-300x200.jpg 300w, https:\/\/www.ainia.com\/wp-content\/uploads\/2026\/02\/nutrigenomica-2-1-1-768x512.jpg 768w, https:\/\/www.ainia.com\/wp-content\/uploads\/2026\/02\/nutrigenomica-2-1-1.jpg 1200w\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><\/p>\n<\/section>\n<\/article>\n<\/body><\/html>","protected":false},"excerpt":{"rendered":"<p>How can genetic data be integrated into dietetic practice? In this article, we explain what nutrigenomics is and show how nucleotides make it possible to define a solid nutrigenetic profile. Based on that foundation, we outline an approach to translating genetic information into personalised recommendations aligned with the principles of precision nutrition. Index Nutrigenomics: what [&hellip;]<\/p>\n","protected":false},"author":1492,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[2],"tags":[],"class_list":["post-188338","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nutrigenomics: How SNPs Define the Nutrigenetic Profile - AINIA<\/title>\n<meta name=\"description\" content=\"Discover what nutrigenomics is, how SNPs help define a nutrigenetic profile, and why this approach is key to delivering personalised precision nutrition strategies.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ainia.com\/en\/ainia-news\/nutrigenomics-what-it-is-and-how-snp-nucleotides-define-the-nutrigenetic-profile-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nutrigenomics: How SNPs Define the Nutrigenetic Profile - AINIA\" \/>\n<meta property=\"og:description\" content=\"Discover what nutrigenomics is, how SNPs help define a nutrigenetic profile, and why this approach is key to delivering personalised precision nutrition strategies.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ainia.com\/en\/ainia-news\/nutrigenomics-what-it-is-and-how-snp-nucleotides-define-the-nutrigenetic-profile-2\/\" \/>\n<meta property=\"og:site_name\" content=\"AINIA\" \/>\n<meta property=\"article:published_time\" content=\"2026-03-09T13:39:16+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-09T13:45:24+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2026\/02\/nutrigenomica-2-1-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"800\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Pablo Estelles\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Pablo Estelles\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.ainia.com\\\/en\\\/ainia-news\\\/nutrigenomics-what-it-is-and-how-snp-nucleotides-define-the-nutrigenetic-profile-2\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ainia.com\\\/en\\\/ainia-news\\\/nutrigenomics-what-it-is-and-how-snp-nucleotides-define-the-nutrigenetic-profile-2\\\/\"},\"author\":{\"name\":\"Pablo Estelles\",\"@id\":\"https:\\\/\\\/www.ainia.com\\\/en\\\/#\\\/schema\\\/person\\\/d96765ddcd986eff4ce2185f4e17192f\"},\"headline\":\"Nutrigenomics: What It Is and How SNP Nucleotides Define the Nutrigenetic Profile\",\"datePublished\":\"2026-03-09T13:39:16+00:00\",\"dateModified\":\"2026-03-09T13:45:24+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.ainia.com\\\/en\\\/ainia-news\\\/nutrigenomics-what-it-is-and-how-snp-nucleotides-define-the-nutrigenetic-profile-2\\\/\"},\"wordCount\":602,\"publisher\":{\"@id\":\"https:\\\/\\\/www.ainia.com\\\/en\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ainia.com\\\/en\\\/ainia-news\\\/nutrigenomics-what-it-is-and-how-snp-nucleotides-define-the-nutrigenetic-profile-2\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.ainia.com\\\/wp-content\\\/uploads\\\/2026\\\/02\\\/nutrigenomica-2-1-1-1024x683.jpg\",\"inLanguage\":\"en\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ainia.com\\\/en\\\/ainia-news\\\/nutrigenomics-what-it-is-and-how-snp-nucleotides-define-the-nutrigenetic-profile-2\\\/\",\"url\":\"https:\\\/\\\/www.ainia.com\\\/en\\\/ainia-news\\\/nutrigenomics-what-it-is-and-how-snp-nucleotides-define-the-nutrigenetic-profile-2\\\/\",\"name\":\"Nutrigenomics: How SNPs Define the Nutrigenetic Profile - 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