{"id":186298,"date":"2026-01-16T13:42:01","date_gmt":"2026-01-16T12:42:01","guid":{"rendered":"https:\/\/www.ainia.com\/?p=186298"},"modified":"2026-01-16T13:59:14","modified_gmt":"2026-01-16T12:59:14","slug":"technological-advances-towards-safe-and-scalable-cultivated-meat","status":"publish","type":"post","link":"https:\/\/www.ainia.com\/en\/ainia-news\/technological-advances-towards-safe-and-scalable-cultivated-meat\/","title":{"rendered":"Technological advances towards safe and scalable cultivated meat"},"content":{"rendered":"<html><body><div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text css=\u201d\u201d]Cultivated meat is becoming a key innovation lever to move towards more sustainable, resilient and efficient food systems. In this context, within the <strong data-start=\"483\" data-end=\"498\">MEAT4FUTURE<\/strong> project we have generated applied knowledge and technological results that bring cultivated meat closer to industrial reality, strengthening <strong data-start=\"640\" data-end=\"691\">process safety, reproducibility and scalability<\/strong>.<\/p>\n<p data-start=\"694\" data-end=\"954\">MEAT4FUTURE has been supported by <strong data-start=\"728\" data-end=\"737\">IVACE<\/strong> and <strong data-start=\"742\" data-end=\"751\">FEDER<\/strong> and developed in collaboration with <strong data-start=\"788\" data-end=\"807\">Industrias Grau<\/strong> and <strong data-start=\"812\" data-end=\"834\">Embutidos Mart\u00ednez<\/strong>, with the aim of providing companies with new methodologies and tools to innovate in the field of alternative proteins.<\/p>\n<p data-start=\"956\" data-end=\"1409\">Through MEAT4FUTURE, we have taken a further step towards transferring cultivated meat to an industrial environment. We have worked on improving the <strong data-start=\"1105\" data-end=\"1144\">quality, efficiency and scalability<\/strong> of the processes involved, while advancing in the <strong data-start=\"1195\" data-end=\"1254\">generation and characterisation of bovine cell cultures<\/strong>, assessing their growth, differentiation and safety, with a clear objective: to equip companies with new capabilities to innovate in alternative proteins.<\/p>\n<p><iframe title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/pR__DQtadU0?si=4xoZ4LV830lqecVQ\" width=\"800\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\" data-mce-fragment=\"1\"><span data-mce-type=\"bookmark\" style=\"display: inline-block; width: 0px; overflow: hidden; line-height: 0;\" class=\"mce_SELRES_start\">\ufeff<\/span><\/iframe><\/p>\n<h2 data-start=\"1416\" data-end=\"1476\"><strong data-start=\"1419\" data-end=\"1476\">Cultivated meat: Safety and reproducibility of the cellular ingredient<\/strong><\/h2>\n<p data-start=\"1478\" data-end=\"1716\">One of the key challenges of cultivated meat is ensuring that the cellular ingredient is developed under <strong data-start=\"1583\" data-end=\"1617\">safe and consistent conditions<\/strong>. Within the project, we identified relevant risks and defined <strong data-start=\"1680\" data-end=\"1715\">control and prevention measures<\/strong>.<\/p>\n<p data-start=\"1718\" data-end=\"2124\">In our trials, we verified the <strong data-start=\"1749\" data-end=\"1776\">absence of contaminants<\/strong> in bovine cell cultures after successive subcultures performed without antibiotics, reinforcing the robustness of the process. In addition, we analysed <strong data-start=\"1929\" data-end=\"1968\">reproducibility in primary cultures<\/strong>, particularly adipose cells, confirming the importance of evaluating each sample individually to ensure consistent behaviour and differentiation potential.<\/p>\n<h3><strong style=\"font-size: 16px;\"><em><img decoding=\"async\" class=\"alignnone wp-image-185729 size-large\" src=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/cultivo-celular-carne-cultivada-1024x576.jpg\" alt=\"cultivo celular carne cultivada\" width=\"1024\" height=\"576\" srcset=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/cultivo-celular-carne-cultivada-1024x576.jpg 1024w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/cultivo-celular-carne-cultivada-300x169.jpg 300w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/cultivo-celular-carne-cultivada-768x432.jpg 768w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/cultivo-celular-carne-cultivada.jpg 1200w\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><\/em><\/strong><\/h3>\n<h3 data-start=\"2131\" data-end=\"2191\"><strong data-start=\"2134\" data-end=\"2191\">Edible scaffolds based on alternative protein sources<\/strong><\/h3>\n<p data-start=\"2193\" data-end=\"2525\">To move closer to more realistic product formats, we worked on the development of <strong data-start=\"2275\" data-end=\"2325\">edible scaffolds based on alternative proteins<\/strong>. Texturised structures were obtained by extrusion from different <strong data-start=\"2391\" data-end=\"2434\">plant-based and microbial raw materials<\/strong>, and the most promising options were selected for validation as <strong data-start=\"2499\" data-end=\"2524\">cell growth scaffolds<\/strong>.<\/p>\n<p data-start=\"2527\" data-end=\"2847\">The trials showed that, when cellular growth is incorporated, attributes such as <strong data-start=\"2608\" data-end=\"2646\">juiciness and texture are enhanced<\/strong>, and a more perceptible <strong data-start=\"2671\" data-end=\"2686\">meaty aroma<\/strong> emerges, especially after cooking. These advances were shared at an international scientific forum within the sector, reinforcing the visibility of the project.<\/p>\n<h3 data-start=\"2854\" data-end=\"2898\"><strong data-start=\"2857\" data-end=\"2898\">Cultivated meat: More efficient and scalable processes<\/strong><\/h3>\n<p data-start=\"2900\" data-end=\"3234\">Another core pillar of the project focused on progressing towards <strong data-start=\"2966\" data-end=\"3007\">more efficient and scalable processes<\/strong>. We worked on <strong data-start=\"3022\" data-end=\"3064\">cell expansion and handling strategies<\/strong> aimed at improving productivity and defining criteria relevant for industrial scale-up, with a strong emphasis on <strong data-start=\"3179\" data-end=\"3233\">operational robustness and process reproducibility<\/strong>.<\/p>\n<h3><strong><img decoding=\"async\" class=\"alignnone wp-image-185734 size-large\" src=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/reactor-carne-cultovada-1024x576.jpg\" alt=\"reactor carne cultivada\" width=\"1024\" height=\"576\" srcset=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/reactor-carne-cultovada-1024x576.jpg 1024w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/reactor-carne-cultovada-300x169.jpg 300w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/reactor-carne-cultovada-768x432.jpg 768w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/reactor-carne-cultovada.jpg 1200w\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><\/strong><\/h3>\n<h3 data-start=\"3241\" data-end=\"3295\"><strong data-start=\"3244\" data-end=\"3295\">Bioreactor optimisation through CFD simulations<\/strong><\/h3>\n<p data-start=\"3297\" data-end=\"3609\">We also generated key results to optimise <strong data-start=\"3339\" data-end=\"3374\">bioreactor design and operation<\/strong> using <strong data-start=\"3381\" data-end=\"3431\">CFD (Computational Fluid Dynamics) simulations<\/strong>. This approach enabled us to analyse mixing and oxygen availability, identifying opportunities to improve process homogeneity and minimise zones with less favourable conditions.<\/p>\n<p data-start=\"3611\" data-end=\"3817\">The work highlights the importance of <strong data-start=\"3649\" data-end=\"3675\">aeration system design<\/strong> and of balancing adequate oxygenation with a <strong data-start=\"3721\" data-end=\"3756\">gentle hydrodynamic environment<\/strong>, which is particularly critical for sensitive cell cultures.<\/p>\n<h3><strong><img decoding=\"async\" class=\"alignnone wp-image-185722 size-large\" src=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/simulaciones-CFD-1024x576.jpg\" alt=\"simulaciones CFD cultivo celular\" width=\"1024\" height=\"576\" srcset=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/simulaciones-CFD-1024x576.jpg 1024w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/simulaciones-CFD-300x169.jpg 300w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/simulaciones-CFD-768x432.jpg 768w, https:\/\/www.ainia.com\/wp-content\/uploads\/2025\/12\/simulaciones-CFD.jpg 1200w\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><\/strong><\/h3>\n<h3 data-start=\"3824\" data-end=\"3864\"><strong>Prototypes and product validation of cultivated meat<\/strong><\/h3>\n<p data-start=\"3866\" data-end=\"4190\">Finally, we addressed post-processing to obtain <strong data-start=\"3914\" data-end=\"3955\">model portions and product prototypes<\/strong>. We evaluated <strong data-start=\"3970\" data-end=\"4017\">biomaterial formulations for 3D bioprinting<\/strong> to simulate \u201csteak-like\u201d structures and, in parallel, developed <strong data-start=\"4082\" data-end=\"4100\">hybrid burgers<\/strong>, comparing 100% plant-based formulations with formulations incorporating cultivated meat.<\/p>\n<p data-start=\"4192\" data-end=\"4666\">The results demonstrate <strong data-start=\"4216\" data-end=\"4267\">technological advantages in hybrid formulations<\/strong>, particularly in terms of compaction, cohesion and structural integrity after cooking. We also identified the need to fine-tune thermal parameters to avoid excessive browning. From a sensory perspective, the overall profile remained similar, with a predominance of plant-based notes, opening up improvement pathways aimed at reinforcing the meaty character without compromising consumer experience.<\/p>\n<h2 data-start=\"4673\" data-end=\"4742\"><strong data-start=\"4676\" data-end=\"4742\">Cultivated meat as a functional ingredient for hybrid matrices<\/strong><\/h2>\n<p data-start=\"4744\" data-end=\"5163\">Overall, the results of MEAT4FUTURE confirm the <strong data-start=\"4792\" data-end=\"4886\">technological feasibility of cultivated meat as a functional ingredient in hybrid matrices<\/strong> and provide relevant advances in <strong data-start=\"4920\" data-end=\"4981\">safety, processing, scalability and prototype development<\/strong>. At <strong data-start=\"4986\" data-end=\"4995\">AINIA<\/strong>, this work reinforces our positioning as a <strong data-start=\"5039\" data-end=\"5074\">technology partner for industry<\/strong> in the development of innovative and sustainable solutions in the field of new proteins.<\/p>\n<p data-start=\"5165\" data-end=\"5545\">The MEAT4FUTURE project has enabled AINIA to advance in the development of <strong data-start=\"5240\" data-end=\"5288\">key knowledge and technological capabilities<\/strong> to drive cultivated meat from a <strong data-start=\"5321\" data-end=\"5366\">safe, scalable and industrial perspective<\/strong>. The results obtained underline the role of <strong data-start=\"5411\" data-end=\"5420\">R&amp;D&amp;I<\/strong> as a driver to address food system challenges and facilitate the transfer of innovative solutions to the business ecosystem.<\/p>\n<p data-start=\"5547\" data-end=\"5953\">This initiative was supported by the <strong data-start=\"5584\" data-end=\"5640\">Conselleria d\u2019Innovaci\u00f3, Ind\u00fastria, Comer\u00e7 i Turisme<\/strong> of the Generalitat Valenciana, through <strong data-start=\"5680\" data-end=\"5689\">IVACE<\/strong>, and co-funded by the <strong data-start=\"5712\" data-end=\"5785\">European Union via the FEDER Comunitat Valenciana 2021\u20132027 Programme<\/strong>, contributing to the positioning of the Valencian Community at the forefront of alternative protein research and the development of more sustainable production models.<\/p>\n<p>\u00a0<\/p>\n<p><img decoding=\"async\" class=\"alignnone wp-image-180198 size-large\" src=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/09\/IVACEUEdeclaracion-cs-negro-1-1024x110.png\" alt=\"logo ivace feder 2025 nuevo\" width=\"1024\" height=\"110\" srcset=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/09\/IVACEUEdeclaracion-cs-negro-1-1024x110.png 1024w, https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/09\/IVACEUEdeclaracion-cs-negro-1-300x32.png 300w, https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/09\/IVACEUEdeclaracion-cs-negro-1-768x82.png 768w, https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/09\/IVACEUEdeclaracion-cs-negro-1-1536x164.png 1536w, https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/09\/IVACEUEdeclaracion-cs-negro-1-2048x219.png 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\">[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div><\/body><\/html>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text css=\u201d\u201d]Cultivated meat is becoming a key innovation lever to move towards more sustainable, resilient and efficient food systems. In this context, within the MEAT4FUTURE project we have generated applied knowledge and technological results that bring cultivated meat closer to industrial reality, strengthening process safety, reproducibility and scalability. MEAT4FUTURE has been supported by IVACE and [&hellip;]<\/p>\n","protected":false},"author":239,"featured_media":185718,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1971],"tags":[],"class_list":["post-186298","post","type-post","status-publish","format-standard","hentry","category-technological-innovation"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Technological advances towards safe and scalable cultivated meat<\/title>\n<meta name=\"description\" content=\"Cultivated meat advances for safe and scalable production: process optimisation, cell culture safety, bioreactors and hybrid product development.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link 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