{"id":183696,"date":"2025-10-31T13:36:06","date_gmt":"2025-10-31T11:36:06","guid":{"rendered":"https:\/\/www.ainia.com\/?p=183696"},"modified":"2026-04-10T10:12:48","modified_gmt":"2026-04-10T09:12:48","slug":"api-pharmaceutical-supercritical-fluid-extraction","status":"publish","type":"post","link":"https:\/\/www.ainia.com\/en\/ainia-news\/api-pharmaceutical-supercritical-fluid-extraction\/","title":{"rendered":"Production of safe and sustainable API Pharmaceuticals"},"content":{"rendered":"<html><body><div class=\"wpb-content-wrapper\"><p><span data-contrast=\"auto\"><span class=\"TextRun SCXW41880406 BCX8\" lang=\"ES-ES\" xml:lang=\"ES-ES\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW41880406 BCX8\"><span class=\"TextRun SCXW194446391 BCX8\" lang=\"ES-ES\" xml:lang=\"ES-ES\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW194446391 BCX8\"><span class=\"TextRun SCXW1005685 BCX8\" lang=\"ES-ES\" xml:lang=\"ES-ES\" data-contrast=\"auto\"><span class=\"NormalTextRun SpellingErrorV2Themed SCXW1005685 BCX8\">[vc_row][vc_column][vc_column_text css=\u201d\u201d]<\/span><\/span><\/span><\/span><\/span><\/span>The growing demand for more sustainable and efficient solutions in the pharmaceutical industry has driven the adoption of clean technologies for the production of <\/span><b><span data-contrast=\"auto\">active ingredients<\/span><\/b><span data-contrast=\"auto\">. One of the most advanced and versatile methods is <\/span><a href=\"https:\/\/www.ainia.com\/en\/technological-services\/industrial-production\/altex\/co2-supercritical-extraction-and-separation\/\"><strong>supercritical fluid extraction<\/strong><\/a><span data-contrast=\"auto\"><strong> (SFE)<\/strong>, especially using carbon dioxide (CO\u2082). This technique enables the recovery of <\/span><b><span data-contrast=\"auto\">API pharmaceuticals<\/span><\/b><span data-contrast=\"auto\"> with high purity, minimizing the use of organic solvents and preserving the integrity of even the most sensitive molecules.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":0,\"335551620\":0,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<h2 aria-level=\"2\"><b><span data-contrast=\"none\">The Role of Supercritical Fluids in API Pharmaceutical Production<\/span><\/b><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"134245418\":true,\"134245529\":true,\"335551550\":0,\"335551620\":0,\"335559738\":299,\"335559739\":299}'>\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Supercritical fluids, particularly <\/span><b><span data-contrast=\"auto\">supercritical carbon dioxide (SC CO\u2082)<\/span><\/b><span data-contrast=\"auto\">, represent a clean, innovative, and scalable technology for extracting <\/span><strong><a href=\"https:\/\/www.ainia.com\/en\/rdi-programme\/health-and-wellness\/health\/ingredients-pharmaceutical-products\/\">API pharmaceuticals<\/a><\/strong><span data-contrast=\"auto\"><strong>.<\/strong> Their advantages include:<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":0,\"335551620\":0,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props='{\"335552541\":1,\"335559683\":0,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}' data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">In its supercritical state, CO\u2082 combines the diffusivity of a gas with the solvating power of a liquid, and its solubility can be finely tuned by adjusting pressure and temperature.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":0,\"335551620\":0,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props='{\"335552541\":1,\"335559683\":0,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}' data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">CO\u2082 is a non-toxic, non-flammable, and fully recyclable solvent, eliminating the need for organic solvents and the generation of harmful waste.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":0,\"335551620\":0,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props='{\"335552541\":1,\"335559683\":0,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}' data-aria-posinset=\"3\" data-aria-level=\"1\"><span data-contrast=\"auto\">It operates at moderate temperatures and without oxygen, which helps preserve heat-sensitive compounds such as vitamins, antioxidants, and other bioactive substances.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":0,\"335551620\":0,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props='{\"335552541\":1,\"335559683\":0,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}' data-aria-posinset=\"4\" data-aria-level=\"1\"><span data-contrast=\"auto\">It enables highly selective extraction\u2014ideal for isolating specific <\/span><b><span data-contrast=\"auto\">active ingredients<\/span><\/b><span data-contrast=\"auto\"> or fractionating compounds based on their chemical profile.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":0,\"335551620\":0,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-setsize=\"-1\" data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"4\" data-list-defn-props='{\"335552541\":1,\"335559683\":0,\"335559684\":-2,\"335559685\":720,\"335559991\":360,\"469769226\":\"Symbol\",\"469769242\":[8226],\"469777803\":\"left\",\"469777804\":\"\uf0b7\",\"469777815\":\"hybridMultilevel\"}' data-aria-posinset=\"5\" data-aria-level=\"1\"><span data-contrast=\"auto\">It allows for microbial inactivation without extreme heat, useful for raw materials requiring pathogen control.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":0,\"335551620\":0,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/li>\n<\/ul>\n<p><span data-contrast=\"auto\">At AINIA\u2019s <\/span><b><span data-contrast=\"auto\">ALTEX platform<\/span><\/b><span data-contrast=\"auto\">, this method is applied from pilot to industrial scale (20\u202fL\u20131,000\u202fL), under ECO and GMP certifications.\u00a0<\/span><\/p>\n<h2 aria-level=\"2\"><b><span data-contrast=\"none\">A Key Technology for a Cleaner and More Competitive Pharmaceutical Industry<\/span><\/b><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"134245418\":true,\"134245529\":true,\"335551550\":0,\"335551620\":0,\"335559738\":299,\"335559739\":299}'>\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Supercritical fluid extraction has emerged as a <\/span><b><span data-contrast=\"auto\">key enabling technology<\/span><\/b><span data-contrast=\"auto\"> for producing <\/span><b><span data-contrast=\"auto\">API pharmaceuticals<\/span><\/b><span data-contrast=\"auto\">. Its ability to combine efficiency, safety, and environmental sustainability positions it as a viable alternative to traditional solvent-based methods\u2014especially in a context where purity, regulatory compliance, and environmental responsibility are essential.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":0,\"335551620\":0,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Moreover, its versatility extends its applicability to industries such as food, cosmetics, and biomedicine, reaffirming its value as a cross-cutting tool for industrial innovation. Integrated into real-world manufacturing processes, it supports the transition toward a cleaner, more competitive, and future-ready industry.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":0,\"335551620\":0,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<h2 aria-level=\"2\"><b><span data-contrast=\"none\">Broader Applications of Supercritical Fluid Extraction<\/span><\/b><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"134245418\":true,\"134245529\":true,\"335551550\":0,\"335551620\":0,\"335559738\":299,\"335559739\":299}'>\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Beyond the pharmaceutical sector, <\/span><strong><a href=\"https:\/\/www.ainia.com\/en\/technological-services\/industrial-production\/altex\/co2-supercritical-extraction-and-separation\/\">supercritical fluids<\/a><\/strong><span data-contrast=\"auto\"> are becoming a versatile tool across various industries. Key applications include:<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":0,\"335551620\":0,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<h3 aria-level=\"3\"><strong>Valorisation of Agricultural By-products\u00a0<\/strong><\/h3>\n<p><span data-contrast=\"auto\">Supercritical CO\u2082 or subcritical water extraction enables the recovery of valuable compounds from agricultural residues\u2014such as onion peels, rice bran, nut shells, or spent coffee grounds\u2014yielding flavonoids, sugars, and other bioactive substances with high functional value.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":0,\"335551620\":0,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<h3 aria-level=\"3\"><strong>Functional Ingredients for Food and Cosmetics\u00a0<\/strong><\/h3>\n<p><span data-contrast=\"auto\">In addition to <\/span><b><span data-contrast=\"auto\">API pharmaceuticals<\/span><\/b><span data-contrast=\"auto\">, SFE is used to obtain pure natural extracts for the food and cosmetics sectors. These include essential oils, antioxidants, pigments, and other <\/span><b><span data-contrast=\"auto\">active ingredients<\/span><\/b><span data-contrast=\"auto\"> for functional formulations.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":0,\"335551620\":0,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<h3 aria-level=\"3\"><strong>Micro- and Nanoparticle Engineering\u00a0<\/strong><\/h3>\n<p><span data-contrast=\"auto\">Advanced technologies like <\/span><b><span data-contrast=\"auto\">SAS (Supercritical Anti-Solvent)<\/span><\/b><span data-contrast=\"auto\"> and <\/span><b><span data-contrast=\"auto\">DELOS<\/span><\/b><span data-contrast=\"auto\"> use supercritical CO\u2082 to produce micro\/nanoparticles, aerogels, and controlled delivery systems. These are used in inhalable therapies, oral formulations, and precision <\/span><b><span data-contrast=\"auto\">API pharmaceutical<\/span><\/b><span data-contrast=\"auto\"> delivery.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":0,\"335551620\":0,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<h3 aria-level=\"3\"><strong>Biomedical Materials and Aerogels\u00a0<\/strong><\/h3>\n<p><span data-contrast=\"auto\">Supercritical CO\u2082 drying is used to produce porous, biocompatible aerogels made from starch, chitosan, or cellulose. These materials are ideal for biomedical applications such as tissue regeneration scaffolds, drug delivery systems, and wound dressings.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":0,\"335551620\":0,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<h3 aria-level=\"3\"><strong>Green Chemistry and Circular Economy\u00a0<\/strong><\/h3>\n<p><span data-contrast=\"auto\">Supercritical fluid processes also contribute to circular economy models. For example, they allow the extraction of high-value compounds from construction waste for the production of insulating aerogels, reducing costs and carbon footprint by up to 40%.<\/span><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335551550\":0,\"335551620\":0,\"335559738\":240,\"335559739\":240}'>\u00a0<\/span><\/p>\n<p><img decoding=\"async\" class=\"alignnone size-large wp-image-142024\" src=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/12\/tecnicos-ainia-2019-parte-IV-11-altex-1024x683.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/12\/tecnicos-ainia-2019-parte-IV-11-altex-1024x683.jpg 1024w, https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/12\/tecnicos-ainia-2019-parte-IV-11-altex-300x200.jpg 300w, https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/12\/tecnicos-ainia-2019-parte-IV-11-altex-768x512.jpg 768w, https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/12\/tecnicos-ainia-2019-parte-IV-11-altex-1536x1024.jpg 1536w, https:\/\/www.ainia.com\/wp-content\/uploads\/2021\/12\/tecnicos-ainia-2019-parte-IV-11-altex-2048x1365.jpg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\"><\/p>\n<p><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335559738\":240,\"335559739\":240}'><span class=\"NormalTextRun SpellingErrorV2Themed SCXW108844792 BCX8\">Funded<\/span><span class=\"NormalTextRun SCXW108844792 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW108844792 BCX8\">by<\/span><span class=\"NormalTextRun SCXW108844792 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW108844792 BCX8\">the<\/span><span class=\"NormalTextRun SCXW108844792 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW108844792 BCX8\">aid<\/span><span class=\"NormalTextRun SCXW108844792 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW108844792 BCX8\">program<\/span><span class=\"NormalTextRun SCXW108844792 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW108844792 BCX8\">for<\/span><span class=\"NormalTextRun SCXW108844792 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW108844792 BCX8\">hiring<\/span><span class=\"NormalTextRun SCXW108844792 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW108844792 BCX8\">young<\/span><span class=\"NormalTextRun SCXW108844792 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW108844792 BCX8\">professionals<\/span><span class=\"NormalTextRun SCXW108844792 BCX8\">\u00a0<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW108844792 BCX8\">specialized<\/span><span class=\"NormalTextRun SCXW108844792 BCX8\">\u00a0in\u00a0<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW108844792 BCX8\">internationalization<\/span><\/span><\/p>\n<p><span data-ccp-props='{\"134233117\":false,\"134233118\":false,\"335559738\":240,\"335559739\":240}'><img decoding=\"async\" class=\"alignnone size-large wp-image-191112\" src=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2026\/02\/Imagen1-1024x109.png\" alt=\"\" width=\"1024\" height=\"109\" srcset=\"https:\/\/www.ainia.com\/wp-content\/uploads\/2026\/02\/Imagen1-1024x109.png 1024w, https:\/\/www.ainia.com\/wp-content\/uploads\/2026\/02\/Imagen1-300x32.png 300w, https:\/\/www.ainia.com\/wp-content\/uploads\/2026\/02\/Imagen1-768x82.png 768w, https:\/\/www.ainia.com\/wp-content\/uploads\/2026\/02\/Imagen1-1536x164.png 1536w, https:\/\/www.ainia.com\/wp-content\/uploads\/2026\/02\/Imagen1.png 1878w\" sizes=\"(max-width: 1024px) 100vw, 1024px\">[\/vc_column_text][\/vc_column][\/vc_row]<\/span><\/p>\n<\/div><\/body><\/html>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text css=\u201d\u201d]The growing demand for more sustainable and efficient solutions in the pharmaceutical industry has driven the adoption of clean technologies for the production of active ingredients. One of the most advanced and versatile methods is supercritical fluid extraction (SFE), especially using carbon dioxide (CO\u2082). This technique enables the recovery of API pharmaceuticals with high [&hellip;]<\/p>\n","protected":false},"author":249,"featured_media":174704,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1971],"tags":[],"class_list":["post-183696","post","type-post","status-publish","format-standard","hentry","category-technological-innovation"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Production of safe and sustainable API Pharmaceuticals<\/title>\n<meta name=\"description\" content=\"Discover how supercritical fluid extraction enables the sustainable, solvent-free production of high-purity API pharmaceuticals and active ingredients.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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