{"id":169735,"date":"2024-04-22T13:55:51","date_gmt":"2024-04-22T11:55:51","guid":{"rendered":"https:\/\/www.ainia.com\/?p=167625"},"modified":"2024-08-05T12:25:01","modified_gmt":"2024-08-05T10:25:01","slug":"extracellular-vesicles-a-new-functional-ingredient-in-the-cosmetics-industry","status":"publish","type":"post","link":"https:\/\/www.ainia.com\/en\/ainia-news\/extracellular-vesicles-a-new-functional-ingredient-in-the-cosmetics-industry\/","title":{"rendered":"Extracellular Vesicles: A New Functional Ingredient in the Cosmetics Industry?"},"content":{"rendered":"

[vc_row][vc_column][vc_column_text]The cosmetics industry requires ingredients that can be produced in sufficient quantities and yields to make the process technically and economically viable. Therefore, the industry is investigating different ingredients that can be scaled up to an industrial level, one of which is extracellular vesicles. After two years of research, we discuss the challenges and future prospects of this compound as a functional ingredient in the cosmetics industry.<\/p>\n

Extracellular Vesicles in Cosmetics: Current Status, Challenges, and Future Perspectives<\/h2>\n

In previous instances, we have discussed the various challenges and advancements surrounding the field of extracellular vesicles (EVs) in different industrial sectors<\/a> (spanish), from functional food to cosmetics, mentioning, of course, the pharmaceutical sector.<\/p>\n

Due to its great potential as a functional ingredient<\/a>, AINIA has worked for over two years on two IVACE-FEDER projects (FIVEX I and FIVEX 2), aiming to design methodologies for obtaining extracellular vesicles<\/a> (spanish), analyzing their potential functionality, and exploring their suitability and scalability to industrial processes.<\/p>\n

Currently, there are various sources for obtaining EVs, as well as methodologies for their extraction. However, not all purification methods allow for scaling up to an industrial level<\/strong>, greatly hindering their implementation as a functional ingredient<\/strong>. This limits their use to applications requiring small quantities or within the context of basic or clinical research.<\/p>\n

Development of a Scalable Isolation Methodology<\/h2>\n

In this regard, one of the main outcomes of the FIVEX projects was the development of a scalable isolation methodology based on anion exchange chromatography. This methodology can be adapted to different sources of extraction, such as probiotic organisms, cells, plant extracts, and mammalian cells.<\/strong><\/p>\n

Furthermore, it was validated that the obtained EVs had functional effects by testing their impact on in vitro culture systems. Various effects were observed, including immunomodulatory, antioxidant, and even whitening effects on induced melanocytes (Results published in the International Society for Extracellular Vesicles (ISEV) 2021 and 2022 congresses).<\/p>\n